Erythropoietin Receptor

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  CYS-28   PHE-29  5.5 5.4 -11.8 2.6 50.1 46.8 29.1  PHE-29   THR-30  3.5 3.8 5.5 -2.4 140.9 142.5 -43.9  THR-30   GLU-31  4.4 4.8 11.9 -18.6 143.8 137.1 37.2 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  GLU-34   ASP-35  10.4 10.9 -9.3 4.8 82.4 73.9 2.9  ASP-35   LEU-36  9.6 10.0 -2.3 1.2 26.2 25.4 28.8  LEU-36   VAL-37  8.9 9.0 2.7 -2.0 104.6 104.7 20.0 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  VAL-118   VAL-119  2.8 3.4 0.4 -7.3 165.1 162.8 50.0  VAL-119   LEU-120  2.7 3.0 11.1 -11.9 101.7 100.0 10.0  LEU-120   LEU-121  1.3 1.1 2.1 -5.3 168.1 164.4 21.6 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  SER-204   PHE-205  13.1 14.2 -66.3 4.9 93.3 84.3 81.4  PHE-205   GLY-206  9.4 10.5 59.9 -88.8 116.5 125.1 139.3  GLY-206   GLY-207  7.3 8.0 -2.3 -10.0 121.9 97.4 -46.8 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees

Residue i Residue i+1 Distance of hinge axis to residue i in conformer 1 (A) Distance of hinge axis to residue i in conformer 2 (A) Change in psi (i) (deg) Change in phi (i+1) (deg) Angle of psi(i) axis to hinge axis conformer 1 (deg) Angle of psi(i) axis to hinge axis conformer 2 (deg) Percentage Progress  PHE-208   TRP-209  5.6 5.0 -5.3 3.1 16.2 23.2 -9.0  TRP-209   SER-210  7.6 7.4 1.1 -14.3 116.8 118.3 23.2  SER-210   ALA-211  6.4 6.4 -7.5 12.1 88.9 81.5 -21.3 Graph shows rotational transition at bending residues and can be used to identify hinge bending residues. Probably only informative for interdomain rotations greater than 20 degrees