Coagulation Factor VIII

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 HIS-660   LYS-661  16.0 19.6 45.8 65.3 106.8 103.4 83.4
 LYS-661   MET-662  19.5 22.9 -28.9 -179.7 29.0 130.3 -11.9
 MET-662   VAL-663  20.5 24.9 -68.3 130.7 88.9 124.1 35.7
 VAL-663   TYR-664  24.0 23.5 -138.0 14.4 135.0 99.6 -88.4
 TYR-664   GLU-665  23.3 20.3 -25.0 -59.7 105.6 49.6 52.2
 GLU-665   ASP-666  20.0 17.7 25.9 14.4 123.5 73.2 24.9
 ASP-666   THR-667  17.6 14.2 179.4 -61.8 79.1 141.1 -12.4
 THR-667   LEU-668  15.3 12.9 -73.3 -46.9 62.1 52.2 76.6
 LEU-668   THR-669  12.1 13.4 44.0 54.6 152.7 156.5 -102.8
 THR-669   LEU-670  13.1 13.2 -41.9 93.4 76.2 62.2 -25.5
 LEU-670   PHE-671  12.9 12.4 13.9 40.1 162.3 162.5 -40.3
 PHE-671   PRO-672  13.3 12.5 72.7 40.0 123.9 102.6 -30.3
 PRO-672   PHE-673  13.1 10.8 5.5 130.8 158.3 99.4 188.2
 PHE-673   SER-674  13.1 13.8 15.9 165.8 116.3 65.3 -38.5
 SER-674   GLY-675  10.8 15.5 -3.9 -172.5 63.5 160.6 -103.1
 GLY-675   GLU-676  12.9 16.3 122.9 5.1 73.6 56.9 55.5
 GLU-676   THR-677  15.2 17.4 -22.1 62.4 172.5 155.4 36.4
 THR-677   VAL-678  16.1 18.4 -38.2 37.3 126.2 127.8 3.1
 VAL-678   PHE-679  17.6 17.0 -1.6 -23.3 145.8 158.3 -17.9
 PHE-679   MET-680  17.3 17.9 -107.2 83.2 127.4 127.8 -11.3
 MET-680   SER-681  17.3 15.2 5.0 -18.9 13.9 25.9 -17.0
 SER-681   MET-682  18.2 15.5 -29.9 57.6 114.3 110.7 10.4
 MET-682   GLU-683  15.0 11.9 42.9 -97.4 6.9 16.0 -51.9
 GLU-683   ASN-684  15.9 11.6 -64.2 -60.6 104.6 95.6 -7.2
 ASN-684   PRO-685  12.4 8.4 35.4 28.4 18.5 93.3 57.6
 PRO-685   GLY-686  11.8 4.9 -177.0 165.0 95.1 47.9 7.2
 GLY-686   LEU-687  8.4 1.5 -54.6 37.3 116.5 34.0 4.8
 LEU-687   TRP-688  4.8 0.7 -90.2 -15.8 49.4 41.9 109.8
 TRP-688   ILE-689  2.3 1.5 -2.2 -176.9 47.9 27.1 -154.1
 ILE-689   LEU-690  1.1 1.0 62.2 -7.8 128.1 123.7 -36.5
 LEU-690   GLY-691  1.8 3.4 -32.6 -27.4 23.5 18.9 48.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 CYS-692   HIS-693  2.8 4.4 -98.6 114.1 149.5 108.4 0.7
 HIS-693   ASN-694  4.4 7.2 -167.7 42.8 158.0 146.3 -118.6
 ASN-694   SER-695  3.7 6.8 52.8 20.6 71.9 83.8 31.6
 SER-695   ASP-696  6.6 7.4 -109.1 78.5 162.9 124.6 -32.9
 ASP-696   PHE-697  6.6 6.1 -90.6 -157.4 114.5 79.4 29.9
 PHE-697   ARG-698  8.0 2.9 71.0 -13.4 99.9 152.5 171.1

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees