Tyrosine-Protein Kinase Btk
(All numbering and residues are taken from first PDB file)
Bending Residue Dihedral Analysis
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
ILE-429
LYS-430
11.3
11.2
9.3
-12.3
102.9
101.7
56.1
LYS-430
MET-431
11.9
12.5
-2.8
-1.2
95.9
93.8
62.2
MET-431
ILE-432
15.6
16.1
-4.8
-14.8
98.1
92.1
-56.3
ILE-432
LYS-433
17.8
18.1
57.7
-95.5
114.1
101.3
101.1
LYS-433
GLU-434
20.8
21.9
7.4
-38.4
53.5
67.0
-139.7
PHE-442
ILE-443
18.0
18.2
0.7
37.8
70.8
7.0
261.7
ILE-443
GLU-444
18.4
19.8
7.7
-52.9
18.8
54.7
-318.2
GLU-444
GLU-445
18.0
16.7
8.3
8.7
85.9
110.2
-144.9
GLU-445
ALA-446
15.0
13.7
-25.2
-11.8
66.7
106.8
-7.8
ALA-446
LYS-447
13.5
12.6
-1.0
4.4
133.8
173.7
13.0
LYS-447
VAL-448
13.5
13.4
-5.0
10.1
118.8
112.4
31.3
VAL-448
MET-449
10.9
10.9
-11.0
3.6
51.1
77.8
31.4
MET-449
MET-450
8.9
8.4
10.2
-11.2
98.3
59.6
-45.3
MET-450
ASN-451
9.1
9.7
4.5
-12.2
49.3
32.5
-41.0
ASN-451
LEU-452
7.2
7.8
4.3
-44.3
95.0
94.6
-13.3
LEU-452
SER-453
4.1
4.5
4.4
-0.7
123.7
121.7
-4.8
SER-453
HIS-454
2.5
2.4
6.6
2.8
87.2
85.3
-20.6
HIS-454
GLU-455
2.5
2.1
6.2
3.6
159.9
151.3
-95.8
GLU-455
LYS-456
5.0
4.8
-1.2
-2.1
48.0
49.2
29.5
LYS-456
LEU-457
4.7
4.3
4.9
-4.8
94.7
99.7
37.8
LEU-457
VAL-458
2.0
1.8
3.8
0.0
127.0
127.6
-75.0
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
ILE-473
THR-474
11.2
11.2
6.1
4.9
63.7
59.0
79.8
THR-474
GLU-475
7.6
7.6
10.5
-21.5
116.6
116.7
121.6
GLU-475
TYR-476
5.4
5.9
13.4
-2.2
156.3
147.1
-134.7
TYR-476
MET-477
4.7
4.8
5.5
5.3
95.5
91.9
-2.5
MET-477
ALA-478
1.4
1.7
4.0
-4.1
164.9
165.2
0.4
ALA-478
ASN-479
2.8
3.3
4.1
-2.4
119.6
118.3
5.3
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees
Residue
iResidue
i+1Distance of hinge axis to residue i in
(A) Distance of hinge axis to residue i in
(A) Change in
(deg) Change in
(deg) Angle of psi(i) axis to hinge axis
(deg) Angle of psi(i) axis to hinge axis
(deg) Percentage Progress
VAL-537
SER-538
6.0
5.9
-2.2
2.0
96.5
97.9
-2.9
SER-538
ASP-539
6.4
6.2
11.3
-6.0
100.5
100.9
-26.3
ASP-539
PHE-540
9.7
9.6
5.6
-28.7
152.0
153.6
193.7
PHE-540
GLY-541
9.8
9.8
-123.3
-160.9
62.3
63.3
-262.0
PHE-559
PRO-560
23.7
23.5
-5.2
-9.9
98.6
104.5
-38.4
PRO-560
VAL-561
21.7
21.6
7.3
4.4
114.1
107.0
11.9
VAL-561
ARG-562
25.0
24.9
-4.9
0.3
89.6
89.1
-28.1
Graph shows rotational transition at bending residues and can be used
to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees