Epidermal Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Bending Residue Dihedral Analysis

Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 LEU-243   MET-244  7.9 5.9 9.6 -26.4 144.2 149.6 117.7
 MET-244   LEU-245  5.7 4.9 10.4 -2.3 136.5 135.5 -66.9
 LEU-245   TYR-246  7.3 6.6 -30.3 26.3 35.1 29.5 24.6

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 TYR-251   GLN-252  2.0 2.0 -3.3 1.4 27.5 37.3 22.9
 GLN-252   MET-253  1.7 1.5 14.3 -14.9 126.8 132.4 35.9
 MET-253   ASP-254  3.0 2.4 36.8 -40.1 108.7 111.4 16.0

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees


Residue
i
Residue
i+1
Distance of hinge axis to residue i in conformer 1
(A)
Distance of hinge axis to residue i in conformer 2
(A)
Change in psi (i)
(deg)
Change in phi (i+1)
(deg)
Angle of psi(i) axis to hinge axis conformer 1
(deg)
Angle of psi(i) axis to hinge axis conformer 2
(deg)
Percentage Progress
 CYS-305   GLU-306  11.6 11.5 -158.4 -157.4 61.6 60.6 -110.6
 GLU-306   GLY-307  14.2 13.7 -92.6 29.0 118.7 136.4 -76.7
 GLY-307   PRO-308  16.6 16.5 120.5 -73.0 47.6 26.5 138.7
 PRO-308   CYS-309  15.3 15.1 26.9 -47.5 54.7 87.3 -18.3
 CYS-309   ARG-310  13.0 12.6 10.1 -5.8 41.2 43.9 12.8
 ARG-310   LYS-311  15.2 14.6 19.6 -18.4 17.2 21.0 -12.0

Downloading Image

Graph shows rotational transition at bending residues and can be used to identify hinge bending residues.
Probably only informative for interdomain rotations greater than 20 degrees