DynDom - Protein Domain Motions

Calcium-Sensing Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Calcium-Sensing Receptor
Conformer 1 (PDB)	7dd6 (A)
Conformer 2 (PDB)	7dd5 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	222	0.92	602 - 759 763 - 814 839 - 861
2	537	0.36	22 - 601 760 - 762
3	24	0.69	815 - 838

Sequence

`________________________________________________________________________________________________________________________` `7dd6(A) : YGPNQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINNSPNLLPNMTLGYRIFDTCNTVSKALEATLSFVAQNKhIPSTIAVVGATGSGVSTAV` `:` `7dd5(A) : YGPNQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWLQAMIFAIEEINNSPNLLPNMTLGYRIFDTCNTVSKALEATLSFVAQNKhIPSTIAVVGATGSGVSTAV` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7dd6(A) : ANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQQVVEVIQNSTARVIVVFSSG` `:` `7dd5(A) : ANLLGLFYIPQVSYASSSRLLSNKNQFKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELISQYSDEEEIQQVVEVIQNSTARVIVVFSSG` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7dd6(A) : PDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPEFFRVIGSTIGFALKAGQIPGFREFLQKVHPKKSANNGFAKEFWEETFNCYpPCTGDENITSVETPYMDFTHLRISYNVYLAVYS` `:` `7dd5(A) : PDLEPLIKEIVRRNITGKIWLASEAWASSSLIAMPEFFRVIGSTIGFALKAGQIPGFREFLQKVHPKKSANNGFAKEFWEETFNCYpPCTGDENITSVETPYMDFTHLRISYNVYLAVYS` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7dd6(A) : IAHALQDIYTCTPGKGLFTNGSCADIKKVEAWQVLKHLRHLNFTSNMGEQVDFDEFGDLVGNYSIINWHLSPEDGSVVFEEVGHYNVYAKKGERLFINENKILWSGFSKEVPFSNCSRDC` `:` `7dd5(A) : IAHALQDIYTCTPGKGLFTNGSCADIKKVEAWQVLKHLRHLNFTSNMGEQVDFDEFGDLVGNYSIINWHLSPEDGSVVFEEVGHYNVYAKKGERLFINENKILWSGFSKEVPFSNCSRDC` `________________________________________________________________________________________________________________________` `_____________________________________________________601________________________________________________________________` `7dd6(A) : LPGTRKGIIEGEPTCCFECVDCPDGEYSDETDASACDKCPEDYWSNENHTSCIPKQIEFLSWTEPFGIALTLFAVLGIFLTSFVLGVFTKFRNTPIVKATNRELSYLLLFSLLCCFSSSL` `:` `7dd5(A) : LPGTRKGIIEGEPTCCFECVDCPDGEYSDETDASACDKCPEDYWSNENHTSCIPKQIEFLSWTEPFGIALTLFAVLGIFLTSFVLGVFTKFRNTPIVKATNRELSYLLLFSLLCCFSSSL` `_____________________________________________________601________________________________________________________________` `_______________________________________________________________________________________759______________________________` `7dd6(A) : FFIGEPQNWTCRLRQPAFGISFVLCISCILVKTNRVLLVFE-------wGLNLQFLLVFLCTFVQIVICVIWLYTAPPSSYRNHELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFF` `:` `7dd5(A) : FFIGEPQNWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEtSLHRKWWGLNLQFLLVFLCTFVQIVICVIWLYTAPPSSYRNHELEDEIIFITCHEGSLMALGFLIGYTCLLAAICFFF` `_______________________________________________________________________________________759______________________________` `______________________814_____________________838_____________________________` `7dd6(A) : AFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKVYIILFKPSRNT` `:` `7dd5(A) : AFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILAASFGLLACIFFNKVYIILFKPSRNT` `______________________814_____________________838_____________________________`

Morph

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Status: Initialising

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	10.5
Translation (A)	-0.1
Closure (%)	10.3
Bending Residues ( green )	601 - 602 759 - 760 762 - 763
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	10.5
Translation (A)	0.4
Closure (%)	95.1
Bending Residues ( green )	814 - 815 838 - 839
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

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