Carboxyl-Terminal Src Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Carboxyl-Terminal Src Kinase
  Conformer 1
(PDB) 		1k9a (A)
  Conformer 2
(PDB) 		1k9a (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 317 0.97   8 - 71   180 - 227   233 - 255   261 - 448
2 118 1.14   72 - 179   228 - 232   256 - 260

Sequence


           __________________________________________________________________71____________________________________________________ 
 1k9a(A) : **ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCE 
         :                                                                                                                          
 1k9a(B) : IQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCE 
           __________________________________________________________________71____________________________________________________ 

           _____________________________________________________179____________________________________________226___232___________ 
 1k9a(A) : GKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL 
         :                                                                                                                          
 1k9a(B) : GKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL 
           _____________________________________________________179____________________________________________226___232___________ 

           _________255____________________________________________________________________________________________________________ 
 1k9a(A) : RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASkLPVKWTAPEALREKKFSTKSDV 
         :                                                                                                                          
 1k9a(B) : RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAgKLPVKWTAPEALREKKFSTKSDV 
           _________255____________________________________________________________________________________________________________ 

           _________________________________________________________________________________                                        
 1k9a(A) : WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL                                        
         :                                                                                                                          
 1k9a(B) : WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL                                        
           _________________________________________________________________________________                                        

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		17.7
Translation
(A) 		0.4
Closure
(%) 		67.1
Bending Residues
( green ) 		  71 - 72
  179 - 180
  226 - 228
  232 - 233
  255 - 263
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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