Glucokinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Glucokinase
  Conformer 1
(PDB) 		3imx (A)
  Conformer 2
(PDB) 		4ise (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 294 1.41   13 - 66   203 - 444
2 122 2.51   67 - 202   445 - 459

Sequence


           _______________________________________________________65_______________________________________________________________ 
 3imx(A) : **GPGSMVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGE-qWSVKTKHQMYSIPEDAMTGTAEMLFDYISECIS 
         :                                                                                                                          
 4ise(A) : KPMPLTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEgQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECIS 
           _______________________________________________________65_______________________________________________________________ 

           ____________________________________________________________________202_________________________________________________ 
 3imx(A) : DFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRM 
         :                                                                                                                          
 4ise(A) : DFLDKHQMKHKKLPLGFTFSFP-------------------------nNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRM 
           ____________________________________________________________________202_________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3imx(A) : CVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRAC 
         :                                                                                                                          
 4ise(A) : CVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRAC 
           ________________________________________________________________________________________________________________________ 

           _________________________________________________________________439__________________________                           
 3imx(A) : ESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKAC****                           
         :                                                                                                                          
 4ise(A) : ESVSTRAAHMCSAGLAGVINRMRESRS--vMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ                           
           _________________________________________________________________439__________________________                           

Morph
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Status: Initialising

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		39.8
Translation
(A) 		0.0
Closure
(%) 		49.9
Bending Residues
( green ) 		  65 - 73
  202 - 204
  439 - 447
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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