DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor 2
Conformer 1 (PDB)	7mtr (A)
Conformer 2 (PDB)	7mtq (A)
Window Length	9
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	220	1.96	188 - 321 450 - 543
2	262	0.58	28 - 187 322 - 449
3	245	1.88	550 - 814

Sequence

`________________________________________________________________________________________________________________________` `7mtr(A) : KKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRAS--tAITGVIGGSYSDVSIQVANLLRLFQIPQIS` `:` `7mtq(A) : KVLTLEGDLVLGGLFPVHQK--pAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLpTAITGVIGGSYSDVSIQVANLLRLFQIPQIS` `________________________________________________________________________________________________________________________` `___________________186__________________________________________________________________________________________________` `7mtr(A) : YASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQR` `:` `7mtq(A) : YASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQR` `___________________186__________________________________________________________________________________________________` `__________________________________321___________________________________________________________________________________` `7mtr(A) : LNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTT` `:` `7mtq(A) : LNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTT` `__________________________________321___________________________________________________________________________________` `________________________________________447_____________________________________________________________________________` `7mtr(A) : RLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAG-gRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIP` `:` `7mtq(A) : RLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWAs--AGPLPASRCSEPCLQNEVKSVQ--eVCCWLCIP` `________________________________________447_____________________________________________________________________________` `_______534______________________________________________________________________________________________________________` `7mtr(A) : CQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFS` `:` `7mtq(A) : CQ---YElDEFTCADCGLG-wPN--lTGCFELPQEYIRW-dAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFS` `_______534______________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7mtr(A) : VCYSALLTKTNRIARIrFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTR-cPENFNEAKFIGFTMYTTCIIWLA` `:` `7mtq(A) : VCYSALLTKTNRIAR----sPASQVAICLALISGQLLIVVAWLVVEAPGT--eTAPERREVVTLRCNHRDASMLGSLAYNVLLI-lCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLA` `________________________________________________________________________________________________________________________` `_______________________________________________` `7mtr(A) : FLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQ` `:` `7mtq(A) : FLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIIL***` `_______________________________________________`

Morph

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Status: Initialising

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	28.3
Translation (A)	0.7
Closure (%)	86.0
Bending Residues ( green )	186 - 188 321 - 323 447 - 453
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	30.2
Translation (A)	-0.8
Closure (%)	71.7
Bending Residues ( green )	534 - 552
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

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