DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor 2
Conformer 1 (PDB)	7mts (A)
Conformer 2 (PDB)	7mtq (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	489	4.38	26 - 551
2	246	1.88	552 - 816

Sequence

`________________________________________________________________________________________________________________________` `7mts(A) : KKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRAS--tAITGVIGGSYSDVSIQVANLLRLFQIPQIS` `:` `7mtq(A) : KVLTLEGDLVLGGLFPVHQK--pAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLpTAITGVIGGSYSDVSIQVANLLRLFQIPQIS` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7mts(A) : YASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQR` `:` `7mtq(A) : YASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQR` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7mts(A) : LNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTT` `:` `7mtq(A) : LNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTT` `________________________________________________________________________________________________________________________` `_________________________________________________________________________________________________________________520____` `7mts(A) : RLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAG-gRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIP` `:` `7mtq(A) : RLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWA--sAGPLPASRCSEPCLQNEVKSVQ--eVCCWLCIP` `_________________________________________________________________________________________________________________520____` `________________________________________________________________________________________________________________________` `7mts(A) : CQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFS` `:` `7mtq(A) : CQ---YElDEFTCADCGLG-wPN--lTGCFELPQEYIRW-dAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFS` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7mts(A) : VCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGF` `:` `7mtq(A) : VCYSALLTKTNRIAR---------------sPASQVAICLALISGQLLIVVAWLVVEAPGT--eTAPERREVVTLRCNHRDASMLGSLAYNVLLI-lCTLYAFKTRKCPENFNEAKFIGF` `________________________________________________________________________________________________________________________` `__________________________________________________________________` `7mts(A) : TMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRA` `:` `7mtq(A) : TMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIIL***********` `__________________________________________________________________`

Morph

Morph animation in progress.
Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.

play backwards

pause

play forwards

Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	37.9
Translation (A)	2.5
Closure (%)	73.0
Bending Residues ( green )	520 - 552
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

Download and extract PyMOL PML script file

Download