DynDom - Protein Domain Motions

Importin Subunit Beta-3

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Importin Subunit Beta-3
Conformer 1 (PDB)	3w3t (A)
Conformer 2 (PDB)	3w3z (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	493	1.31	522 - 527 529 - 1086
2	484	1.19	6 - 521 528 - 528

Sequence

`________________________________________________________________________________________________________________________` `3w3t(A) : LPEEVNRTLLQIVQAFAS-dNQIRSVAEKALSEEWeNNIEYLLTFLAEQAAFSQDTTVAALSAVLFRKLALKAPITHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECVQDDLPA` `:` `3w3z(A) : LPEEVNRTLLQIVQAFASPDNQIRSVAEKALSEEWeNNIEYLLTFLAEQAAFSQDTTVAALSAVLFRKLALK--iTHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECVQDDLPA` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3t(A) : WPELLQALIESLKSGNPNFRESSFRILTTVPYLITAVDINSILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLGILLPSLLNSLPRFLDDGKDDALASVFESLIELVELAPKL` `:` `3w3z(A) : WPELLQALIESLKSGNPNFRESSFRILTTVPYLIT-------lPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLGILLPSLLNSLPRFLDDGKDDALASVFESLIELVELAPKL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3t(A) : FKDMFDQIIQFTDMVIKNKDLEPPARTTALELLTVFSENAPQMCKSNQNYGQTLVMVTLIMMTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYLQQMI` `:` `3w3z(A) : FKD-fDQIIQFTD-vIKNKDLEPPARTTALELLTVFSENAPQ-cKSNQNYGQTLV-vTLI--tEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYLQQ-i` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3t(A) : TSTEWRERFAAMMALSSAAEGCADVLIGEIPKILDMVIPLINDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILEPYLDSLLT` `:` `3w3z(A) : TSTEWRERFAA--aLSSAAEGCADVLIGEIPKILD-vIPLINDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILEPYLDSLLT` `________________________________________________________________________________________________________________________` `______________513_______________________________________________________________________________________________________` `3w3t(A) : NLLVLLQSNKLYVQEQALTTIAFIAEAAKNKFIKYYDTLMPLLLNVLKVnSVLKGKCMECATLIGFAVGKEKFHEHSQELISILVALQNSDdDALRSYLEQSWSRICRILGDDFVPLLPI` `:` `3w3z(A) : NLLVLLQSNKLYVQEQALTTIAFIAEAAKNKFIKYYDTL-pLLLNVLK-nSVLKGKC-eCATLIGFAVGKEKFHEHSQELISILVALQNSDd-ALRSYLEQSWSRICRILGDDFVPLLPI` `______________513_______________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3t(A) : VIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDDKVSAMELLQSYATLLRGQFAVYVKEVMEEIALPSLDFYLHDGVRAAGATLIPILLSCLLAATeELVLLW` `:` `3w3z(A) : VIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDDKVSA-eLLQSYATLLRGQFAVYVKEV-eEIALPSLDFYLHDGVRAAGATLIPILLSCLLAATeELVLLW` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3t(A) : HKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGVSANLTDTYERMQDRdEYNEfTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWPMINTFLLDNEPILVIF` `:` `3w3z(A) : HKASSKLIGGL-sEP-pEITQVYHNSLVNGIKV-gDNCLSEDQLAAFTKGVSANLTDTYER-qDR-----fTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWP-iNTFLL---pILVIF` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3t(A) : ALVVIGDLIQYeQTASMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYADVCIPTLDTLVQIVDgSKLEENRSSTENASAAIAKILYAY-----dTYTANWFKTLPTITDKEA` `:` `3w3z(A) : ALVVIGDLIQYeQTAS-kNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYADVCIPTLDTLVQIVDgSKLEENRSSTENASAAIAKILYAYNSNIPdTYTANWFKTLPTITDKEA` `________________________________________________________________________________________________________________________` `___________________________________________________________________________` `3w3t(A) : ASFNYQFLSQLIENsNISAVVDSVIQALNERSLt----VISSVKKLLGFLPSSDAMAIFNRYPADIMEKVHKWFA` `:` `3w3z(A) : ASFNYQFLSQLI--sNISAVVDSVIQALNERSLTEREtVISSVKKLLGFLPSSDA-aIFNRYPADI-eKVHKWF*` `___________________________________________________________________________`

Morph

Jmol._Canvas2D (Jmol) "jmolApplet"[x]

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	37.0
Translation (A)	-0.5
Closure (%)	90.5
Bending Residues ( green )	513 - 529
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

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