DynDom - Protein Domain Motions

Importin Subunit Beta-3

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Importin Subunit Beta-3
Conformer 1 (PDB)	3w3t (A)
Conformer 2 (PDB)	3w3x (A)
Window Length	9
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	605	1.09	14 - 72 91 - 622 683 - 691 730 - 731 806 - 807 809 - 832
2	396	1.34	73 - 79 623 - 682 692 - 729 732 - 805 808 - 808 833 - 1084

Sequence

`__________________________________________________________________72_____79_____________________________________________` `3w3t(A) : LPEEVNRTLLQIVQAFASdNQIRSVAEKALSEEW--eNNIEYLLTFLAEQAAFSQDTTVAALSAVLFRKLALKAPITHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECVQDDLP` `:` `3w3x(A) : *EEVNRTLLQIVQAFASdNQIRSVAEKALSEEWITENNIEYLLTFLAEQAAFSQDTTVAALSAVLFRKLALKAPITHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECVQDDLP` `__________________________________________________________________72_____79_____________________________________________` `________________________________________________________________________________________________________________________` `3w3t(A) : AWPELLQALIESLKSGNPNFRESSFRILTTVPYLITAVDINSILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLGILLPSLLNSLPRFLDDGKDDALASVFESLIELVELAPK` `:` `3w3x(A) : AWPELLQALIESLKSGNPNFRESSFRILTTVPYLITAVDINSILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLGILLPSLLNSLPRFLDDGKDDALASVFESLIELVELAPK` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3t(A) : LFKDMFDQIIQFTDMVIKNKDLEPPARTTALELLTVFSENAPQMCKSNQNYGQTLVMVTLIMMTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYLQQM` `:` `3w3x(A) : LFKDMFDQIIQFTDMVIKNKDLEPPARTTALELLTVFSENAPQMCKSNQNYGQTLVMVTLIMMTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYLQQM` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3t(A) : ITSTEWRERFAAMMALSSAAEGCADVLIGEIPKILDMVIPLINDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILEPYLDSLL` `:` `3w3x(A) : ITSTEWRERFAAMMALSSAAEGCADVLIGEIPKILDMVIPLINDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILEPYLDSLL` `________________________________________________________________________________________________________________________` `_____________________________________________________________________________________________________________________622` `3w3t(A) : TNLLVLLQSNKLYVQEQALTTIAFIAEAAKNKFIKYYDTLMPLLLNVLKVnSVLKGKCMECATLIGFAVGKEKFHEHSQELISILVALQNSDdDALRSYLEQSWSRICRILGDDFVPLLP` `:` `3w3x(A) : TNLLVLLQSNKLYVQEQALTTIAFIAEAAKNKFIKYYDTLMPLLLNVLKVnSVLKGKCMECATLIGFAVGKEKFHEHSQELISILVALQNSd--ALRSYLEQSWSRICRILGDDFVPLLP` `_____________________________________________________________________________________________________________________622` `_________________________________________________________682______691___________________________________729_____________` `3w3t(A) : IVIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDDKVSAMELLQSYATLLRGQFAVYVKEVMEEIALPSLDFYLHDGVRAAGATLIPILLSCLLAATeELVLL` `:` `3w3x(A) : IVIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDDKVSAMELLQSYATLLRGQFAVYVKEVMEEIALPSLDFYLHDGVRAAGATLIPILLSCLLAA-eELVLL` `_________________________________________________________682______691___________________________________729_____________` `________________________________________________________805______________832____________________________________________` `3w3t(A) : WHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGVSANLTDTYERMQDRdEYNE-fTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWPMINTFLLDNEPILV` `:` `3w3x(A) : WHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGVSANLTDTYERMQDRdEYNEdFTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWPMINTFLL--ePILV` `________________________________________________________805______________832____________________________________________` `________________________________________________________________________________________________________________________` `3w3t(A) : IFALVVIGDLIQYeQTASMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYADVCIPTLDTLVQIVDgSKLEENRSSTENASAAIAKILYAY-----dTYTANWFKTLPTITDK` `:` `3w3x(A) : IFALVVIGDLIQYeQTASMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYADVCIPTLDTLVQIVD-sKLEENRSSTENASAAIAKILYAYNSNIPdTYTANWFKTLPTITDK` `________________________________________________________________________________________________________________________` `_________________________________________________________________________` `3w3t(A) : EAASFNYQFLSQLIENsNISAVVDSVIQALNERSLtVISSVKKLLGFLPSSDAMAIFNRYPADIMEKVHKWFA` `:` `3w3x(A) : EAASFNYQFLSQ---qSNISAVVDSVIQALNERSLtVISSVKKLLGFLPSSDAMAIFNRYPADIMEKVHKWF` `_________________________________________________________________________`

Morph

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This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	4.7
Translation (A)	0.2
Closure (%)	84.5
Bending Residues ( green )	72 - 77 79 - 91 622 - 623 682 - 683 691 - 692 729 - 732 805 - 820 832 - 833
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

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