DynDom - Protein Domain Motions

Actin, Alpha Skeletal Muscle

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Actin, Alpha Skeletal Muscle
Conformer 1 (PDB)	8f8p (E)
Conformer 2 (PDB)	8vkh (E)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	204	0.75	35 - 39 53 - 67 139 - 282 284 - 291 295 - 324 339 - 340
2	162	0.8	7 - 34 40 - 52 68 - 138 283 - 283 292 - 294 325 - 338 341 - 373

Sequence

`_____________________________34___39___________52_____________67________________________________________________________` `8f8p(E) : *TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEgIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMF` `:` `8vkh(E) : ETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEgIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMF` `_____________________________34___39___________52_____________67________________________________________________________` `___________138__________________________________________________________________________________________________________` `8f8p(E) : ETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPD` `:` `8vkh(E) : ETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPD` `___________138__________________________________________________________________________________________________________` `___________________________________282______291______________________________324___________338__________________________` `8f8p(E) : GQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDE` `:` `8vkh(E) : GQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDE` `___________________________________282______291______________________________324___________338__________________________` `___________` `8f8p(E) : AGPSIVHRKCF` `:` `8vkh(E) : AGPSIVHRKCF` `___________`

Morph

Jmol._Canvas2D (Jmol) "jmolApplet"[x]

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	6.2
Translation (A)	0.1
Closure (%)	70.0
Bending Residues ( green )	34 - 35 39 - 44 52 - 53 67 - 68 138 - 139 282 - 284 291 - 292 294 - 295 324 - 329 338 - 341
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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