Calmodulin-Like Domain Protein Kinase Isoform 3

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Calmodulin-Like Domain Protein Kinase Isoform 3
  Conformer 1
(PDB) 		3dxn (A)
  Conformer 2
(PDB) 		3hzt (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 169 1.42   77 - 83   102 - 167   187 - 283
2 81 2.02   22 - 76   84 - 101   168 - 186

Sequence


           ________________________________________________________76_____83_______________101_____________________________________ 
 3dxn(A) : LSDRYQRVKKLGS--yGEVLLCKDK-tGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLH 
         :                                                                                                                          
 3hzt(A) : *SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLH 
           _______________________________________________________129____136_______________154_____________________________________ 

           __________________________167______184__________________________________________________________________________________ 
 3dxn(A) : KHNIVHRDLKPENLLLESKS-dALIKIVDFGLSAHFeRLGTAYYIAPEVLRKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVKLMLTYEP 
         :                                                                                                                          
 3hzt(A) : KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFE-VgTAYYIAPEVLRKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAKQLVKLMLTYEP 
           __________________________220______229__________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3dxn(A) : SKRISAEEALNHPWIVKFCSQK************************************************************************************************** 
         :                                                                                                                          
 3hzt(A) : SKRISAEEALNHPWIVKFCSQvGKHALTGALGNMKKFQSSQKLAQAAMLFMGSKLTTLEETKELTQIFRQLDNNGDGQLDRKELIEGYRKLMQWsSQIEAEVDHILQSVDFrNGYIEYSE 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________________                                                          
 3dxn(A) : ***************************************************************                                                          
         :                                                                                                                          
 3hzt(A) : FVTVCMDKQLLLSRERLLAAFQQFDSDGSGKITNEELGRLFGVTEgEVDFEEFVEMMQKICDV                                                          
           _______________________________________________________________                                                          

Morph

Jmol._Canvas2D (Jmol) "jmolApplet"[x]

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		18.2
Translation
(A) 		-0.9
Closure
(%) 		39.4
Bending Residues
( green ) 		  76 - 77
  83 - 84
  101 - 103
  167 - 168
  184 - 187
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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