DynDom - Protein Domain Motions

Elongation Factor 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Elongation Factor 2
Conformer 1 (PDB)	1n0v (D)
Conformer 2 (PDB)	1zm9 (C)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	483	0.68	4 - 482 731 - 732 734 - 735 759 - 763 765 - 765 785 - 796
2	82	0.98	483 - 559 729 - 730 772 - 773 779 - 779
3	249	0.81	563 - 728 733 - 733 736 - 758 764 - 764 766 - 770 774 - 778 780 - 784 797 - 840

Sequence

`________________________________________________________________________________________________________________________` `1n0v(D) : VAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKgITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCV` `:` `1zm9(C) : VAFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISA--gITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCV` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1n0v(D) : QTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKTKKW` `:` `1zm9(C) : QTETVLRQALGERIKPVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQVYPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFNPKTKKW` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1n0v(D) : TNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIKNCDPKAD` `:` `1zm9(C) : TNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEKLEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYRAEQLYEGPADDANCIAIKNCDPKAD` `________________________________________________________________________________________________________________________` `______________________________________________________________________________________________________482_______________` `1n0v(D) : LMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSPVVQVAVEVKN` `:` `1zm9(C) : LMLYVSKMVPTSDKGRFYAFGRVFAGTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGNIIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSPVVQVAVEVKN` `______________________________________________________________________________________________________482_______________` `___________________________________________________________559__________________________________________________________` `1n0v(D) : ANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLAIENGIINPRDDFKARAR` `:` `1zm9(C) : ANDLPKLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEICLQDLEHDHAGVPLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLAIENGIINPRDDFKARAR` `___________________________________________________________559__________________________________________________________` `______________________________________________________________________________________________________________730_______` `1n0v(D) : IMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGGGQIIPTMRRATYAGFLLADPKIQEPVFLVEIQCPE` `:` `1zm9(C) : IMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKAVQYLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAI-rGGGQIIPTMRRATYAGFLLADPKIQEPVFLVEIQCPE` `______________________________________________________________________________________________________________730_______` `__________________758__763____770_____778___784_________796______________________________________________` `1n0v(D) : QAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKRHGMKEEVPGWQEYYDKL` `:` `1zm9(C) : QAVGGIYSVLNKKRGQVVSEEQRPGTPLFTVKAYLPVNESFGFTGELRQATGGQAFPQMVFDHWSTLGSDPLDPTSKAGEIVLAARKRHGMKEEVPGWQEYYDKL` `__________________758__763____770_____778___784_________796______________________________________________`

Morph

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Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Fixed Domain	Moving Domain	Rotation Angle	Translation (A)	Closure	Bending Residues
1	2	11.7	0.0	12.4	482 - 483 730 - 731	Bending Region Analysis
1	3	8.7	-0.5	22.7	732 - 737 758 - 759 763 - 766 784 - 785 796 - 797	Bending Region Analysis
2	3	9.7	0.0	70.1	559 - 563 728 - 729 770 - 774 778 - 780	Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 2 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 2

Movement classification:

No Contacts

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