Geranylgeranyltransferase Type I Alpha Subunit

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Geranylgeranyltransferase Type I Alpha Subunit
  Conformer 1
(PDB) 		1tno (K)
  Conformer 2
(PDB) 		2f0y (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 146 0.53   133 - 135   140 - 278   281 - 284
2 80 0.7   57 - 132   136 - 139
3 35 0.6   279 - 280   285 - 315   318 - 319
4 46 0.58   316 - 317   320 - 363

Sequence


           ___________________________________________________________________________132____139___________________________________ 
 1tno(K) : FLSLDSPTYVLYRDRAEWADIDPVPQNDGPSPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYIIAIIEEQPKNYQVWHHRRV 
         :                                                                                                                          
 2f0y(A) : FVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRV 
           ___________________________________________________________________________132____139___________________________________ 

           _____________________________________________________________________________________________________278___284__________ 
 1tno(K) : LVEWLKDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPN 
         :                                                                                                                          
 2f0y(A) : LVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPN 
           _____________________________________________________________________________________________________278___284__________ 

           __________________315_____________________________________________________                                               
 1tno(K) : LLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHS                                               
         :                                                                                                                          
 2f0y(A) : LLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHS                                               
           __________________315_____________________________________________________                                               

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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 9.1 -0.5 80.2   132 - 133   135 - 136   139 - 140 Bending Region Analysis
1 3 6.2 -0.7 99.5   278 - 281   284 - 287 Bending Region Analysis
3 4 6.5 -0.5 34.6   315 - 320 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 3 ———› Residue 4

Conformer 2 Contact:
Residue 4 ———› Residue 3

Movement classification: Hinge

PyMOL Script

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