Hexokinase-2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Hexokinase-2
  Conformer 1
(PDB)
2nzt (A)
  Conformer 2
(PDB)
2nzt (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 433 0.38   19 - 461
2 427 0.34   462 - 911

Sequence


           ________________________________________________________________________________________________________________________ 
 2nzt(A) : DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVvEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQI 
         :                                                                                                                          
 2nzt(B) : DQVQKVDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVvEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQI 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2nzt(A) : KDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGA 
         :                                                                                                                          
 2nzt(B) : KDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGA 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2nzt(A) : FGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSA 
         :                                                                                                                          
 2nzt(B) : FGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISDIEGE-dGIRKAREVLMRLGLDPTQEDCVATHRICQIVSTRSA 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________________________________________461__________________________________________ 
 2nzt(A) : SLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKET 
         :                                                                                                                          
 2nzt(B) : SLCAATLAAVLQRIKENKGE--lRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLEHLQLSHDQLLEVKRRMKVEMERGLSKET 
           ___________________________________________________________________________461__________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2nzt(A) : HASAPVKMLPTYVCgDFLALDLGGTNFRVLLVRVRgVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGM---sLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTL 
         :                                                                                                                          
 2nzt(B) : HASAPVKMLPTYVCgDFLALDLGGTNFRVLLVRV--vEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTL 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2nzt(A) : LKEAIHRRdLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILI 
         :                                                                                                                          
 2nzt(B) : LKEAIHRR--dVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILI 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2nzt(A) : DFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETV 
         :                                                                                                                          
 2nzt(B) : DFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETV 
           ________________________________________________________________________________________________________________________ 

           __________________________________                                                                                       
 2nzt(A) : KDLAPKCDVSFLQSEDGSGKGAALITAVACRIRE                                                                                       
         :                                                                                                                          
 2nzt(B) : KDLAPKCDVSFLQSEDGSGKGAALITAVACRIRE                                                                                       
           __________________________________                                                                                       

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
2.7
Translation
(A)
1.1
Closure
(%)
98.4
Bending Residues
( green )
  461 - 462
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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