3-Hydroxyisobutyrate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name 3-Hydroxyisobutyrate Dehydrogenase
  Conformer 1
(PDB)
2gf2 (A)
  Conformer 2
(PDB)
2i9p (D)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 150 0.39   117 - 121   143 - 144   147 - 149   186 - 190   195 - 203   205 - 330
2 137 0.4   44 - 116   122 - 142   145 - 146   150 - 185   191 - 194   204 - 204

Sequence


           __________________________________________________________________________116_______________________142_________________ 
 2gf2(A) : MPVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPV 
         :                                                                                                                          
 2i9p(D) : MPVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPV 
           __________________________________________________________________________116_______________________142_________________ 

           _______________________185__190_194__199________________________________________________________________________________ 
 2gf2(A) : SGGVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGT 
         :                                                                                                                          
 2i9p(D) : SGGVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGT 
           _______________________185__190_194__199________________________________________________________________________________ 

           ________________________________________________________                                                                 
 2gf2(A) : TLMAKDLGLAQDSATSTKSPILLGSLAHQIYRMMCAKGYSKKDFSSVFQFLREEET                                                                 
         :                                                                                                                          
 2i9p(D) : TLMAKDLGLAQDSATSTKSPILLGSLAHQIYRMMCAKGYSKKDFSSVFQFLRE***                                                                 
           ________________________________________________________                                                                 

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
4.8
Translation
(A)
0.3
Closure
(%)
99.3
Bending Residues
( green )
  116 - 122
  142 - 150
  185 - 186
  190 - 191
  194 - 196
  199 - 205
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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