DynDom - Protein Domain Motions

Importin Alpha Subunit

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Importin Alpha Subunit
Conformer 1 (PDB)	1wa5 (B)
Conformer 2 (PDB)	1ee5 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	253	0.7	245 - 245 249 - 254 261 - 270 273 - 508
2	164	0.69	92 - 244 246 - 248 255 - 260 271 - 272

Sequence

`________________________________________________________________________________________________________________________` `1wa5(B) : fVPEYRRTeLRRRRDTQQVELRKAKRDEALAKRRNFqELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVV` `:` `1ee5(A) : *************************************PQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVV` `________________________________________________________________________________________________________________________` `_______________________________________________________________________244_248___254___260______269_____________________` `1wa5(B) : DADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQE` `:` `1ee5(A) : DADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQE` `_______________________________________________________________________244_248___254___260______269_____________________` `________________________________________________________________________________________________________________________` `1wa5(B) : AIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNA` `:` `1ee5(A) : AIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEDKTKKEACWAISNA` `________________________________________________________________________________________________________________________` `_______________________________________________________________________________________________________` `1wa5(B) : SSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFGEEE` `:` `1ee5(A) : SSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFG*` `_______________________________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	7.6
Translation (A)	-0.2
Closure (%)	96.4
Bending Residues ( green )	244 - 246 248 - 249 254 - 255 260 - 261 269 - 273
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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