Importin-Alpha2 Subunit

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Importin-Alpha2 Subunit
  Conformer 1
(PDB)
2c1m (A)
  Conformer 2
(PDB)
1y2a (C)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 89 0.52   184 - 254   263 - 271   274 - 276   282 - 287
2 107 0.56   77 - 183
3 223 0.68   255 - 262   272 - 273   277 - 281   288 - 495

Sequence


           __________________________________________________________________________________________________________183___________ 
 2c1m(A) : NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGS 
         :                                                                                                                          
 1y2a(C) : NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGS 
           __________________________________________________________________________________________________________183___________ 

           _________________________________________________________254_258__________271__276__281_________________________________ 
 2c1m(A) : AFRDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPAL 
         :                                                                                                                          
 1y2a(C) : AFRDLVIKHGAIDPLLALLAVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPAL 
           _________________________________________________________254_258__________271__276__281_________________________________ 

           ________________________________________________________________________________________________________________________ 
 2c1m(A) : RAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDT 
         :                                                                                                                          
 1y2a(C) : RAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMNLLSAKDT 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________                                                         
 2c1m(A) : KIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHENESVYKASLNLIEKYFSV                                                         
         :                                                                                                                          
 1y2a(C) : KIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQRHENESVYKASLNLIEKYFS*                                                         
           ________________________________________________________________                                                         

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
9.3
Translation
(A)
-0.4
Closure
(%)
99.7
Bending Residues
( green )
  183 - 184
Bending Region Analysis
Property Value
Fixed Domain
( blue )
1
Moving Domain
( yellow )
3
Rotation Angle
(deg)
10.4
Translation
(A)
-0.4
Closure
(%)
97.5
Bending Residues
( green )
  254 - 255
  258 - 264
  271 - 274
  276 - 277
  281 - 288
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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