DynDom - Protein Domain Motions

Cytochrome B-245 Heavy Chain

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Cytochrome B-245 Heavy Chain
Conformer 1 (PDB)	8x2l (B)
Conformer 2 (PDB)	8wej (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	120	1.64	285 - 396 416 - 427 452 - 455
2	271	0.84	10 - 284
3	117	0.78	397 - 415 436 - 446 456 - 566

Sequence

`________________________________________________________________________________________________________________________` `8x2l(B) : ****EGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSS----tRVRRQLDRNLTFHKMVAWMIALHSAIHTIAHLF` `:` `8wej(B) : GNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTFHKMVAWMIALHSAIHTIAHLF` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `8x2l(B) : NVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGVVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHNI` `:` `8wej(B) : NVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGVVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHNI` `________________________________________________________________________________________________________________________` `_________________________________277____________________________________________________________________________________` `8x2l(B) : TVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDW` `:` `8wej(B) : TVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDW` `_________________________________277____________________________________________________________________________________` `____________________________392____________________415_________427________________446______455__________________________` `8x2l(B) : TEGLFNACGCDk--------LPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYLT` `:` `8wej(B) : TEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYLT` `____________________________392____________________415_________427________________446______455__________________________` `_________________________________________________________________________________________` `8x2l(B) : G------------------------qKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKE` `:` `8wej(B) : GWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF` `_________________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	15.7
Translation (A)	0.2
Closure (%)	10.0
Bending Residues ( green )	277 - 285
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	17.4
Translation (A)	-0.9
Closure (%)	55.2
Bending Residues ( green )	392 - 398 415 - 416 427 - 436 446 - 453 455 - 456
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Shear

PyMOL Script

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