Glucokinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Glucokinase
  Conformer 1
(PDB) 		4ise (A)
  Conformer 2
(PDB) 		1v4t (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 313 3.08   17 - 71   93 - 99   204 - 459
2 100 3.77   72 - 92   100 - 203

Sequence


           _____________________________________________________________71_________________90______________________________________ 
 4ise(A) : KPMPLTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEg---QWSVKTKHQMYSIPEDAMTGTAEMLFDYISE 
         :                                                                                                                          
 1v4t(A) : ******MVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISE 
           _____________________________________________________________71_________________90______________________________________ 

           _________________________________________195____________________________________________________________________________ 
 4ise(A) : CISDFLDKHQMKHKKLPLGFTFSFP--nNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLL 
         :                                                                                                                          
 1v4t(A) : CISDFLDKHQMKHKKLPLGFTFSFPVRHnVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLL 
           _________________________________________195____________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 4ise(A) : EYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVIN 
         :                                                                                                                          
 1v4t(A) : EYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVIN 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________________________________                                               
 4ise(A) : RMRESRS--vMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ                                               
         :                                                                                                                          
 1v4t(A) : RMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKAC****                                               
           __________________________________________________________________________                                               

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		68.7
Translation
(A) 		2.7
Closure
(%) 		96.6
Bending Residues
( green ) 		  71 - 72
  90 - 102
  195 - 204
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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