DynDom - Protein Domain Motions

Excinuclease Abc Subunit A

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Excinuclease Abc Subunit A
Conformer 1 (PDB)	2r6f (A)
Conformer 2 (PDB)	3uwx (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	812	0.7	4 - 129 246 - 947
2	68	1.21	130 - 245

Sequence

`________________________________________________________________________________________________________________________` `2r6f(A) : *DKIIVKGARAHNLKNIDVEIPRGKLVVLTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQ-eKPDVDAIEGLSPAISIDQKTTSRNPRSTVGTVTEIYDYLRLLFARIGRPIC` `:` `3uwx(A) : MDKIIVKGARAHNLKNIDVEIPRGKLVVLTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMEKPDVDAIEGLSPAISIDQKTTSRNPRSTVGTVTEIYDYLRLLFARIGRPIC` `________________________________________________________________________________________________________________________` `______129_______________________________________________________________________________________________________________` `2r6f(A) : PTHGIEIQSQTIEQ-vDRLLSYPERTK-qILAPi----------------------------------------------DVVVDRIIIKDGIAARLADSLETALKLADGKVVVDVIGEG` `:` `3uwx(A) : PTHGIEIQSQTIEQMVDRLLSYPERTKMQILAPIVSGKKGTHAKTLEDIRKQGYVRVRIDREMRELTGDIELEKNKKHSIDVVVDRIIIKDGIAARLADSLETALKLADGKVVVDVIGEG` `______129_______________________________________________________________________________________________________________` `__245___________________________________________________________________________________________________________________` `2r6f(A) : ELLFSEKHACPYCGFSIGELEPRLFSFNSPFGACPDCDGLGAKLEVDLDLVIPNDELTLKEHAIAPWEPyYPQLLEAVCRHYGIP-dVPVKDLPKEQLDKILYGSGGEPIYFRYTNDFGQ` `:` `3uwx(A) : ELLFSEKHACPYCGFSIGELEPRLFSFNSPFGACPDCDGLGAKLEVDLDLVIPNDELTLKEHAIAPWEPyYPQLLEAVCRHYGIPMDVPVKDLPKEQLDKILYGSGGEPIYFRYTNDFGQ` `__245___________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2r6f(A) : VREQYIAFEGVIPNVERRYRETSSDYIREQ-eKY-aEQPCPTCQGYRLKKESLAVLVGGKHIGEVTA-sVTEALAFFDGLELTEKEAQIARLILREIRDRLGFLQNVGLDYLTLSRSAGT` `:` `3uwx(A) : VREQYIAFEGVIPNVERRYRETSSDYIREQMEKYMAEQPCPTCQGYRLKKESLAVLVGGKHIGEVTAMSVTEALAFFDGLELTEKEAQIARLILREIRDRLGFLQNVGLDYLTLSRSAGT` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2r6f(A) : LSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLIATLKS-rDLGNTLIVVEHDEDT-lAADYLIDIGPGAGIHGGEVVAAGTPEEV-nDPNSLTGQYLSGKKFIPIPAERRR` `:` `3uwx(A) : LSGGEAQRIRLATQIGSRLTGVLYVLDEPSIGLHQRDNDRLIATLKSMRDLGNTLIVVEHDEDTMLAADYLIDIGPGAGIHGGEVVAAGTPEEVMNDPNSLTGQYLSGKKFIPIPAERRR` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2r6f(A) : PDGRWLEVVGAREHNLKNVSVKIPLGTFVAVTGVSGSGKSTLVNEVLYKALAQKLHRAKAKPGEHRDIRGLEHLDKVIDIDQSPIGRTPRSNPATYTGVFDDIRDVFASTNEAKVRGYKK` `:` `3uwx(A) : PDGRWLEVVGAREHNLKNVSVKIPLGTFVAVTGVSGSGKSTLVNEVLYKALAQKLHRAKAKPGEHRDIRGLEHLDKVIDIDQSPIGRTPRSNPATYTGVFDDIRDVFASTNEAKVRGYKK` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2r6f(A) : GRFSFNVKGGRCEACHGDGIIKIE-hFLPDVYVPCEVCHGKRYNRETLEVTYKGKNIAEVLD-tVEDALDFFASIPKIKRKLETLYDVGLGY-kLGQPATTLSGGEAQRVKLAAELHRRS` `:` `3uwx(A) : GRFSFNVKGGRCEACHGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKNIAEVLDMTVEDALDFFASIPKIKRKLETLYDVGLGYMKLGQPATTLSGGEAQRVKLAAELHRRS` `________________________________________________________________________________________________________________________` `_________________________________________________________________________________________________________` `2r6f(A) : NGRTLYILDEPTTGLHVDDIARLLDVLHRLVDNGDTVLVIEHNLDVIKTADYIIDLGPEGGDRGGQIVAVGTPEEVAEVKESHTGRYLKPILERDRAR-qARYEA` `:` `3uwx(A) : NGRTLYILDEPTTGLHVDDIARLLDVLHRLVDNGDTVLVIEHNLDVIKTADYIIDLGPEGGDRGGQIVAVGTPEEVAEVKESHTGRYLKPILERDRARMQARYEA` `_________________________________________________________________________________________________________`

Morph

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This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	29.6
Translation (A)	0.4
Closure (%)	59.5
Bending Residues ( green )	129 - 130 245 - 249
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

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