DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor 5

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor 5
Conformer 1 (PDB)	8x0b (A)
Conformer 2 (PDB)	8x0b (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	522	0.98	27 - 514 521 - 534 539 - 548 557 - 559 570 - 574 579 - 587 631 - 635 644 - 646 721 - 728
2	254	1.15	515 - 520 535 - 538 549 - 556 560 - 569 575 - 578 588 - 630 636 - 643 647 - 720 729 - 825

Sequence

`________________________________________________________________________________________________________________________` `8x0b(A) : RRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLkPIVGVIGPGSSSVAIQVQNLLQLFNI` `:` `8x0b(B) : RRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLkPIVGVIGPGSSSVAIQVQNLLQLFNI` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `8x0b(A) : PQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLL` `:` `8x0b(B) : PQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `8x0b(A) : MAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSM` `:` `8x0b(B) : MAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSM` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________514___520___526_` `8x0b(A) : AYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTAFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGE` `:` `8x0b(B) : AYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTAFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGE` `________________________________________________________________________________________________________514___520___526_` `________538______547______556__________569______578_582_____________________________________________630__________643____` `8x0b(A) : VSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQ` `:` `8x0b(B) : VSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQ` `________538______547______556__________569______578_582_____________________________________________630__________643____` `______________________________________________________________________720_______________________________________________` `8x0b(A) : RIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVAPLGYNGLLILACTFYAFKTRNVPAN` `:` `8x0b(B) : RIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVAPLGYNGLLILACTFYAFKTRNVPAN` `______________________________________________________________________720_______________________________________________` `____________________________________________________________` `8x0b(A) : FNEAKYIAFAMYTTCIIWLAFVPIYFGSNYKAITMCFSVSLSATVLLGCMFVPKVYIILA` `:` `8x0b(B) : FNEAKYIAFAMYTTCIIWLAFVPIYFGSNYKAITMCFSVSLSATVLLGCMFVPKVYIILA` `____________________________________________________________`

Morph

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This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	11.7
Translation (A)	0.0
Closure (%)	36.7
Bending Residues ( green )	514 - 515 520 - 523 526 - 535 538 - 543 547 - 549 556 - 561 569 - 575 578 - 579 582 - 588 630 - 636 643 - 644 646 - 647 720 - 729
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

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