DynDom - Protein Domain Motions

Actin Alpha 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Actin Alpha 1
Conformer 1 (PDB)	2oan (A)
Conformer 2 (PDB)	3hbt (A)
Window Length	9
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	162	0.44	140 - 192 211 - 238 250 - 330 332 - 332
2	154	0.51	10 - 139 331 - 331 333 - 367
3	21	0.73	201 - 210 239 - 249

Sequence

`________________________________________________________________________________________________________________________` `2oan(A) : AALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRkDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYV` `:` `3hbt(A) : TTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPR-dSYVGDEAQSKRGILTLKYPIE-gIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYV` `________________________________________________________________________________________________________________________` `__139__________________________________________________192_______________210_______________________236__________249_____` `2oan(A) : AIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNER` `:` `3hbt(A) : AIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNER` `__139__________________________________________________192_______________210_______________________236__________249_____` `_________________________________________________________________________330____________________________________________` `2oan(A) : FRCPEALFQPSFLGMES-gIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVH*` `:` `3hbt(A) : FRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKC` `_________________________________________________________________________330____________________________________________` `_` `2oan(A) : ` `:` `3hbt(A) : F` `_`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	4.2
Translation (A)	0.1
Closure (%)	32.9
Bending Residues ( green )	139 - 140 330 - 333
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	9.8
Translation (A)	0.1
Closure (%)	76.9
Bending Residues ( green )	192 - 201 210 - 211 236 - 239 249 - 252
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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