DynDom - Protein Domain Motions

Actin Alpha 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Actin Alpha 1
Conformer 1 (PDB)	2oan (A)
Conformer 2 (PDB)	3j8i (D)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	232	1.72	8 - 10 13 - 15 79 - 86 99 - 100 106 - 106 118 - 126 128 - 136 143 - 178 182 - 336 340 - 343 346 - 348
2	115	1.53	11 - 12 16 - 78 87 - 98 101 - 105 107 - 117 127 - 127 137 - 142 179 - 181 337 - 339 344 - 345 349 - 365

Sequence

`________10___15_____________________________________________________________78______86__________98____105_________117___` `2oan(A) : ***AALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPR----------kDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT` `:` `3j8i(D) : DEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMT` `________10___15_____________________________________________________________78______86__________98____105_________117___` `__125________136___142_________________________________178______________________________________________________________` `2oan(A) : QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY` `:` `3j8i(D) : QIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSY` `__125________136___142_________________________________178______________________________________________________________` `_____________________________________________________________________________________________336____343__348____________` `2oan(A) : ELPDGQVITIGNERFRCPEALFQPSFLGMES-gIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ` `:` `3j8i(D) : ELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQ` `_____________________________________________________________________________________________336____343__348____________` `_______________` `2oan(A) : EYDESGPSIVH**` `:` `3j8i(D) : EYDEAGPSIVHRKCF` `_______________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	14.4
Translation (A)	0.1
Closure (%)	26.2
Bending Residues ( green )	10 - 13 15 - 16 78 - 79 86 - 87 98 - 101 105 - 107 117 - 118 125 - 128 136 - 137 142 - 143 178 - 179 181 - 182 336 - 337 339 - 340 343 - 346 348 - 349
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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