DynDom - Protein Domain Motions

Pre-Mrna-Splicing Factor Atp-Dependent RNA Helicase Dhx15

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Pre-Mrna-Splicing Factor Atp-Dependent RNA Helicase Dhx15
Conformer 1 (PDB)	6sh6 (A)
Conformer 2 (PDB)	6sh7 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	513	0.65	111 - 315 394 - 398 445 - 457 498 - 787
2	148	0.37	316 - 393 399 - 444 458 - 497

Sequence

`________________________________________________________________________________________________________________________` `6sh6(A) : PHMLEQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCS` `:` `6sh7(A) : *HMLEQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCS` `________________________________________________________________________________________________________________________` `_____________________________________________________________________________________315________________________________` `6sh6(A) : SAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEE` `:` `6sh7(A) : SAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEE` `_____________________________________________________________________________________315________________________________` `___________________________________________393_______________________________________________444________455_____________` `6sh6(A) : EEGDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKqNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQ` `:` `6sh7(A) : EEGDLLLFLTGQEEIDEACKRIKREVDD--------kIIPLYSTLPPQQQQRIFEPPP-----aIGRKVVVSTNIAETSLTI--vVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQ` `___________________________________________393_______________________________________________444________455_____________` `__________________________497___________________________________________________________________________________________` `6sh6(A) : RAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVL` `:` `6sh7(A) : RAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVL` `__________________________497___________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6sh6(A) : SITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTG` `:` `6sh7(A) : SITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTG` `________________________________________________________________________________________________________________________` `_________________________________________________________________________________` `6sh6(A) : HYLTVKDNQVVQLHPSTVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYYDMSNFPQCEAKRQLDRIIAKLQS` `:` `6sh7(A) : HYLTVKDNQVVQLHPSTVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYYDMSNFPQCEAKRQLDRIIAKLQS` `_________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	7.8
Translation (A)	0.2
Closure (%)	45.5
Bending Residues ( green )	315 - 316 393 - 399 444 - 445 455 - 458 497 - 498
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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