DynDom - Protein Domain Motions

Threonyl-Trna Synthetase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Threonyl-Trna Synthetase
Conformer 1 (PDB)	1qf6 (A)
Conformer 2 (PDB)	1nyr (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	390	1.92	243 - 471 476 - 636
2	232	1.95	4 - 242 472 - 475

Sequence

`________________________________________________________________________________________________________________________` `1qf6(A) : *PVITLPDGSQRHYDHAVSPMDVALDIGPGLAKACIAGRVNGELVDACDLIENDAQLSIITAKDEEGLEIIRHSCAHLLGHAIKQLWPHTKMAIGPVIDNGFYYDVDLDRTLTQEDVE` `:` `1nyr(B) : MEQINIQFPDGNKKAFDKGTTTEDIAQSISPGLRKKAVAGKFNGQLVDLTKPLETDGSIEIVTPGSEEALEVLRHSTAHLMAHAIKRLYGNVKFGVGPVIEGGFYYDFDIDQNISSDDFE` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1qf6(A) : ALEKRMHELAEKNYDVIKKKVSWHEARETFANRGESYKVSILDENIAHDDKPGLYFHEEYVDMCRGPHVPNMRFCHHFKLMKTAGAYWRGDSNNKMLQRIYGTAWADKKALNAYLQRLEE` `:` `1nyr(B) : QIEKTMKQIVNENMKIERKVVSRDEAKE----------LeLIDA-IPEDENVTLYSQGDFTDLCRGVHVPSTAKIKEFKLLSTAGAYWRGDSNNKMLQRIYGTAFFDKKELKAHLQMLEE` `________________________________________________________________________________________________________________________` `_242____________________________________________________________________________________________________________________` `1qf6(A) : AAKRDHRKIGKQLDLY-HMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSS--ENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRM` `:` `1nyr(B) : RKERDHRKIGKELELFTNSQLVGAGLPLWLPNGATIRREIERYIVDKEVSMGYDHVYTPVLANVDLYKTSGHWDHYQEDMFPPMQLDETESMVLRPMNCPHHMMIYANKPHSYRELPIRI` `_241____________________________________________________________________________________________________________________` `_____________________________________________________________________________________________________________________471` `1qf6(A) : AEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTR-PE---KRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLY` `:` `1nyr(B) : AELGTMHRYEASGAVSGLQRVRGMTLNDSHIFVRPDQIKEEFKRVVNMIIDVYKDFGFEDYSFRLSYRDPEDKEKYFDDDDMWNKAENMLKEAADELGLSYEEAIGEAAFYGPKLDVQVK` `_____________________________________________________________________________________________________________________477` `________________________________________________________________________________________________________________________` `1qf6(A) : DCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQVVIMNIT-DSQSEYVNELTQKLSNAGIRVKADLRNEKIGFKIREHTLRRV` `:` `1nyr(B) : TAMGKEETLSTAQLDFLLPERFDLTYIGQDGEHHRPVVIHRGVVSTMERFVAFLTEETKGAFPTWLAPKQVQIIPVNVDLHYDYARQLQDELKSQGVRVSIDDRNEKMGYKIREAQMQKI` `________________________________________________________________________________________________________________________` `____________________________________________________` `1qf6(A) : PYMLVCGDKEVESGKVAVRTRRGKDLGSMDVNEVIEKLQQEIRSRSLKQLEE` `:` `1nyr(B) : PYQIVVGDKEVENNQVNVRQYGSQDQETVEKDEFIWNLVDEIRLKKHR**` `____________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	22.0
Translation (A)	0.2
Closure (%)	32.6
Bending Residues ( green )	242 - 243 471 - 477
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

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