Alcohol Dehydrogenase Class III

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Alcohol Dehydrogenase Class III
  Conformer 1
(PDB) 		4dla (B)
  Conformer 2
(PDB) 		4dlb (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 24 0.71   50 - 61   359 - 370
2 181 0.29   5 - 49   62 - 97   100 - 103   109 - 110   119 - 156   160 - 177   325 - 358   374 - 377
3 168 0.28   98 - 99   104 - 108   111 - 118   157 - 159   178 - 324   371 - 373

Sequence


           __________________________________________44_______________61__________________________________97___103________114______ 
 4dla(B) : SATQGQVITCKAAVAWEPNKPLVIEDVQVAPPQAGEVRVKVLYTALCHTDAYTWSGKDPEGLFPCVLGHEAAGIVESVGEGVTEVQPGDHVIPCYQAECRECKFCKSGKTNLCGKVRAAT 
         :                                                                                                                          
 4dlb(A) : SATQGQVITCKAAVAWEPNKPLVIEDVQVAPPQAGEVRVKVLYTALCHTDAYTWSGKDPEGLFPCVLGHEAAGIVESVGEGVTEVQPGDHVIPCYQAECRECKFCKSGKTNLCGKVRAAT 
           __________________________________________44_______________61__________________________________97___103________114______ 

           _________________________________156__________________177_______________________________________________________________ 
 4dla(B) : GVGVMMNDRKSRFSINGKPIYHFMGTSTFSQYTVVHDVSVAKIDPVAPLEKVCLLGCGVPTGLGAVWNTAKVEPGSIVAVFGLGTVGLAVAEGAKAAGASRIIGIDIDSKKFDRAKNFGV 
         :                                                                                                                          
 4dlb(A) : GVGVMMNDRKSRFSINGKPIYHFMGTSTFSQYTVVHDVSVAKIDPVAPLEKVCLLGCGVPTGLGAVWNTAKVEPGSIVAVFGLGTVGLAVAEGAKAAGASRIIGIDIDSKKFDRAKNFGV 
           _________________________________156__________________177_______________________________________________________________ 

           _________________________________________________________________________________324_______________________________358__ 
 4dla(B) : TEFINPKEHEQPIQQVIVDLTDGGVDYSFECIGNVSVMRSALECCHKGWGTSVIVGVAASGQEISTRPFQLVTGRVWKGTAFGGFKSRSQVPSLVDKYLKKEIKVDEYITHNMTLADINK 
         :                                                                                                                          
 4dlb(A) : TEFINPKEHEQPIQQVIVDLTDGGVDYSFECIGNVSVMRSALECCHKGWGTSVIVGVAASGQEISTRPFQLVTGRVWKGTAFGGFKSRSQVPSLVDKYLKKEIKVDEYITHNMTLADINK 
           _________________________________________________________________________________324_______________________________358__ 

           _______370_________                                                                                                      
 4dla(B) : AFDLMHDGDCLRVVLDMFV                                                                                                      
         :                                                                                                                          
 4dlb(A) : AFDLMHDGDCLRVVLDMFV                                                                                                      
           _______370_________                                                                                                      

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 5.8 0.1 7.0   44 - 50   61 - 62   358 - 359 Bending Region Analysis
1 3 9.1 -0.8 97.0   370 - 372 Bending Region Analysis
2 3 4.4 0.0 82.9   97 - 100   103 - 111   114 - 120   156 - 157   159 - 160   177 - 178   324 - 325   373 - 374 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 2 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 2

Movement classification: Hinge

PyMOL Script

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