DynDom - Protein Domain Motions

Alcohol Dehydrogenase Class III

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Alcohol Dehydrogenase Class III
Conformer 1 (PDB)	4dla (B)
Conformer 2 (PDB)	4dlb (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	189	0.37	40 - 46 73 - 75 98 - 99 111 - 113 157 - 159 177 - 329 347 - 355 368 - 373 375 - 377
2	184	0.32	5 - 39 47 - 72 76 - 97 100 - 110 114 - 156 160 - 176 330 - 346 356 - 367 374 - 374

Sequence

`_____________________________________39_____46________________________72_75____________________97__________110__________` `4dla(B) : SATQGQVITCKAAVAWEPNKPLVIEDVQVAPPQAGEVRVKVLYTALCHTDAYTWSGKDPEGLFPCVLGHEAAGIVESVGEGVTEVQPGDHVIPCYQAECRECKFCKSGKTNLCGKVRAAT` `:` `4dlb(B) : SATQGQVITCKAAVAWEPNKPLVIEDVQVAPPQAGEVRVKVLYTALCHTDAYTWSGKDPEGLFPCVLGHEAAGIVESVGEGVTEVQPGDHVIPCYQAECRECKFCKSGKTNLCGKVRAAT` `_____________________________________39_____46________________________72_75____________________97__________110__________` `_________________________________156_________________176________________________________________________________________` `4dla(B) : GVGVMMNDRKSRFSINGKPIYHFMGTSTFSQYTVVHDVSVAKIDPVAPLEKVCLLGCGVPTGLGAVWNTAKVEPGSIVAVFGLGTVGLAVAEGAKAAGASRIIGIDIDSKKFDRAKNFGV` `:` `4dlb(B) : GVGVMMNDRKSRFSINGKPIYHFMGTSTFSQYTVVHDVSVAKIDPVAPLEKVCLLGCGVPTGLGAVWNTAKVEPGSIVAVFGLGTVGLAVAEGAKAAGASRIIGIDIDSKKFDRAKNFGV` `_________________________________156_________________176________________________________________________________________` `______________________________________________________________________________________329______________346______355_____` `4dla(B) : TEFINPKEHEQPIQQVIVDLTDGGVDYSFECIGNVSVMRSALECCHKGWGTSVIVGVAASGQEISTRPFQLVTGRVWKGTAFGGFKSRSQVPSLVDKYLKKEIKVDEYITHNMTLADINK` `:` `4dlb(B) : TEFINPKEHEQPIQQVIVDLTDGGVDYSFECIGNVSVMRSALECCHKGWGTSVIVGVAASGQEISTRPFQLVTGRVWKGTAFGGFKSRSQVPSLVDKYLKKEIKVDEYITHNMTLADINK` `______________________________________________________________________________________329______________346______355_____` `__365_____373______` `4dla(B) : AFDLMHDGDCLRVVLDMFV` `:` `4dlb(B) : AFDLMHDGDCLRVVLDMFV` `__365_____373______`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	2.7
Translation (A)	0.0
Closure (%)	58.0
Bending Residues ( green )	39 - 40 46 - 47 72 - 73 75 - 76 97 - 100 110 - 111 113 - 114 156 - 157 159 - 160 176 - 177 329 - 330 346 - 347 355 - 356 365 - 371 373 - 377
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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