Aldose Reductase, Akr4c7

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Aldose Reductase, Akr4c7
  Conformer 1
(PDB) 		5jh1 (A)
  Conformer 2
(PDB) 		5jh2 (A)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 226 0.29   5 - 218   239 - 280
2 21 0.21   219 - 238   281 - 281

Sequence


           ________________________________________________________________________________________________________________________ 
 5jh1(A) : ARHFVLNTGAKIPSVGLGSWQSDPGVVGNAVYAAVKAGYRHIDCARVYGNEKEIGLALKKLFEEGVVKREDMFITSKLWND---pEDVPEALNDSLNDLQLEYLDLYLIHWPF-pATWGA 
         :                                                                                                                          
 5jh2(A) : ARHFVLNTGAKIPSVGLGSWQSDPGVVGNAVYAAVKAGYRHIDCARVYGNEKEIGLALKKLFEEGVVKREDMFITSKLWNDHHAPEDVPEALNDSLNDLQLEYLDLYLIHWPFfPATWGA 
           ________________________________________________________________________________________________________________________ 

           _____________________________________________________________________________218_________________238____________________ 
 5jh1(A) : MEKLYDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPGWQQTKLHSFCQSTGVHLTAYSPLGSPGTTWMNGNVLKEPIIISIAEKLGKTSAQVALRWNIQMGHSVLPKSTNEER 
         :                                                                                                                          
 5jh2(A) : MEKLYDAGKARAIGVSNFSSKKLGDLLAVARVPPAVDQVECHPGWQQTKLHSFCQSTGVHLTAYSPLG---------nVLKEPIIISIAEKLGKTSAQVALRWNIQMGHSVLPKSTNEER 
           _____________________________________________________________________________218_________________238____________________ 

           ___________________280____                                                                                               
 5jh1(A) : IKQNLDVYDWSIPDDLLAKFSEIKQA                                                                                               
         :                                                                                                                          
 5jh2(A) : IKQNLDVYDWSIPDDLLAKFSEIKQA                                                                                               
           ___________________280____                                                                                               

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		4.1
Translation
(A) 		-0.1
Closure
(%) 		41.5
Bending Residues
( green ) 		  218 - 219
  238 - 239
  280 - 281
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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