Anti-Cd33 Conditional Scfv

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Anti-Cd33 Conditional Scfv
  Conformer 1
(PDB) 		6uy3 (A)
  Conformer 2
(PDB) 		8vev (A)
  Window Length 13
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 104 1.74   8 - 114
2 49 14.07   115 - 187

Sequence


           _________________________________________________________________________________________________________________114____ 
 6uy3(A) : *VQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMHWVRQAPGKGLEWVAVISY--DGRLKYYADSVKGRFTISRDNAEYLVYLQMNSLRAEDTAVYYCAAEEGDGGFFDYWGQGTLVTVS 
         :                                                                                                                          
 8vev(A) : EVKLEESGGGLVQPGGSMKLSCVASGFSFTNYWMNWVRQSPEKGLEWVAEISLKSSNYVTYYAESVKGRFTISSDKSKRSVYLQMNNLRAEDTGIYFCSLWQT---WFAYWGQGTLVTVS 
           _________________________________________________________________________________________________________________113____ 

           ________________________________________________________________________________________________________________________ 
 6uy3(A) : SGsVLTQPPS----ASGTPGQR---VTISCSGSSSNIGSNYVNWYQQLPGTAPKLLIYRNNERPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDGSLSGRGVFGTGTKLTVLE 
         :                                                                                                                          
 8vev(A) : SAK--TTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPR***************** 
           ________________________________________________________________________________________________________________________ 

           ______                                                                                                                   
 6uy3(A) : NLYFQG                                                                                                                   
         :                                                                                                                          
 8vev(A) : ******                                                                                                                   
           ______                                                                                                                   

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		53.2
Translation
(A) 		-19.4
Closure
(%) 		97.2
Bending Residues
( green ) 		  114 - 119
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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