Beta-Adrenergic Receptor Kinase 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Beta-Adrenergic Receptor Kinase 1
  Conformer 1
(PDB)
1ym7 (C)
  Conformer 2
(PDB)
1omw (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 304 0.57   186 - 213   217 - 255   258 - 514
2 294 0.75   31 - 185   214 - 216   256 - 257   515 - 654

Sequence


           ________________________________________________________________________________________________________________________ 
 1ym7(C) : SKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQP 
         :                                                                                                                          
 1omw(A) : SKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQP 
           ________________________________________________________________________________________________________________________ 

           _________________________________184__________________________213_______________________________________255_____________ 
 1ym7(C) : YIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLS 
         :                                                                                                                          
 1omw(A) : YIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLS 
           _________________________________184__________________________213_______________________________________255_____________ 

           ________________________________________________________________________________________________________________________ 
 1ym7(C) : FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGH 
         :                                                                                                                          
 1omw(A) : FILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGH 
           ________________________________________________________________________________________________________________________ 

           _________________________________________________________________________________________________________514____________ 
 1ym7(C) : SPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGkGIKLLDSDQELYRNFPLTISERWQQEVAETVF 
         :                                                                                                                          
 1omw(A) : SPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRG--iKLLDSDQELYRNFPLTISERWQQEVAETVF 
           _________________________________________________________________________________________________________514____________ 

           ________________________________________________________________________________________________________________________ 
 1ym7(C) : DTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNtQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRD 
         :                                                                                                                          
 1omw(A) : DTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMG---wQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRD 
           ________________________________________________________________________________________________________________________ 

           ___________________                                                                                                      
 1ym7(C) : AYREAQQ************                                                                                                      
         :                                                                                                                          
 1omw(A) : AYREAQQLVQRVPKMKNKP                                                                                                      
           ___________________                                                                                                      

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
8.2
Translation
(A)
-0.1
Closure
(%)
32.9
Bending Residues
( green )
  184 - 186
  213 - 214
  216 - 217
  255 - 259
  514 - 515
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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