Cyclin-Dependent Kinase 7

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Cyclin-Dependent Kinase 7
  Conformer 1
(PDB) 		8r9a (A)
  Conformer 2
(PDB) 		8r9b (A)
  Window Length 11
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 254 1.06   15 - 156   178 - 306
2 21 4.23   157 - 177

Sequence


           ________________________________________________________________________________________________________________________ 
 8r9a(A) : *********KRYEKLDFLGEG--aTVYKARDKNTNQIVAIKK---nRTALREIKLLQELSHPNIIGLLDAFG--sNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 
         :                                                                                                                          
 8r9b(A) : MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLnRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQ 
           ________________________________________________________________________________________________________________________ 

           _____________________154____________________177_________________________________________________________________________ 
 8r9a(A) : HRILHRDLKPNNLLLDENGVLKLADFGLAKSFGDPNRAYEHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFK 
         :                                                                                                                          
 8r9b(A) : HWILHRDLKPNNLLLDENGVLKLADFGLAKSFGDPNRAYEHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFK 
           _____________________154____________________177_________________________________________________________________________ 

           _____________________________________________________________                                                            
 8r9a(A) : SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPN                                                            
         :                                                                                                                          
 8r9b(A) : SFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPN                                                            
           _____________________________________________________________                                                            

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		90.1
Translation
(A) 		1.6
Closure
(%) 		97.9
Bending Residues
( green ) 		  154 - 157
  177 - 178
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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