Cyclin-Dependent Kinase 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Cyclin-Dependent Kinase 2
  Conformer 1
(PDB) 		1fin (A)
  Conformer 2
(PDB) 		1hck (A)
  Window Length 11
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 191 0.62   57 - 62   86 - 142   166 - 293
2 20 2.62   33 - 56
3 50 1.06   6 - 32   63 - 85

Sequence


           ______________________________32______________________56___________________________85___________________________________ 
 1fin(A) : MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 
         :                                                                                                                          
 1hck(A) : MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIR----tEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 
           ______________________________32______________________56___________________________85___________________________________ 

           ________________________________________________________________________________________________________________________ 
 1fin(A) : HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 
         :                                                                                                                          
 1hck(A) : HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________________                                                               
 1fin(A) : PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL                                                               
         :                                                                                                                          
 1hck(A) : PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL                                                               
           __________________________________________________________                                                               

Morph

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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 34.2 1.8 75.3   56 - 62 Bending Region Analysis
1 3 13.6 -0.3 99.6   57 - 63   85 - 87 Bending Region Analysis
2 3 38.1 0.0 89.9   32 - 33 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 2 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 2

Movement classification: Hinge

PyMOL Script

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