E3 Ubiquitin-Protein Ligase Cbl

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name E3 Ubiquitin-Protein Ligase Cbl
  Conformer 1
(PDB) 		5hkw (A)
  Conformer 2
(PDB) 		3buw (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 222 0.82   50 - 260   271 - 273   294 - 301
2 76 0.47   261 - 270   274 - 293   302 - 347

Sequence


           ________________________________________________________________________________________________________________________ 
 5hkw(A) : *PGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK 
         :                                                                                                                          
 3buw(B) : PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK 
           ________________________________________________________________________________________________________________________ 

           ______________________________________________________________________________________255___________269_________________ 
 5hkw(A) : GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH 
         :                                                                                                                          
 3buw(B) : GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH 
           ______________________________________________________________________________________255___________269_________________ 

           ____293____300___________________________________________________                                                        
 5hkw(A) : KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDL**                                                        
         :                                                                                                                          
 3buw(B) : KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTG                                                        
           ____293____300___________________________________________________                                                        

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		15.5
Translation
(A) 		0.2
Closure
(%) 		54.0
Bending Residues
( green ) 		  255 - 262
  269 - 276
  293 - 298
  300 - 302
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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