Focal Adhesion Kinase 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Focal Adhesion Kinase 1
  Conformer 1
(PDB) 		4k9y (A)
  Conformer 2
(PDB) 		2j0l (A)
  Window Length 11
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 238 1.45   420 - 563   587 - 680
2 21 4.89   564 - 586

Sequence


           ________________________________________________________________________________________________________________________ 
 4k9y(A) : ****YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQL 
         :                                                                                                                          
 2j0l(A) : STRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQL 
           ________________________________________________________________________________________________________________________ 

           ___________________________560_______________________586________________________________________________________________ 
 4k9y(A) : STALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPT 
         :                                                                                                                          
 2j0l(A) : STALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDST--kASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPT 
           ___________________________560_______________________586________________________________________________________________ 

           ____________________________________                                                                                     
 4k9y(A) : LYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKA*                                                                                     
         :                                                                                                                          
 2j0l(A) : LYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKLQ                                                                                     
           ____________________________________                                                                                     

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		50.0
Translation
(A) 		1.1
Closure
(%) 		52.5
Bending Residues
( green ) 		  560 - 564
  586 - 587
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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