DynDom - Protein Domain Motions

Importin-5

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Importin-5
Conformer 1 (PDB)	6xte (A)
Conformer 2 (PDB)	9im6 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	383	1.7	215 - 219 222 - 222 224 - 224 233 - 240 248 - 253 257 - 636 835 - 837
2	138	1.25	84 - 108 119 - 121 125 - 163 165 - 214 220 - 221 223 - 223 225 - 232 241 - 247 254 - 256
3	463	1.57	637 - 834 848 - 1113
4	75	1.3	23 - 83 109 - 118 122 - 124 164 - 164

Sequence

`______________________________________________________________83______________________108_______118___124_______________` `6xte(A) : AMAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNLI` `:` `9im6(A) : *AAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNLI` `______________________________________________________________83______________________108_______118___124_______________` `_____________________163________________________________________________214__219__________232_____240____247___253______` `6xte(A) : DEDGNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSLV` `:` `9im6(A) : DEDGNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQCMQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSLV` `_____________________163________________________________________________214__219__________232_____240____247___253______` `________________________________________________________________________________________________________________________` `6xte(A) : EIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLE--------------dFDSNAVAGESALDRMACGLGGKLVLPMIKE` `:` `9im6(A) : EIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLPMIKE` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6xte(A) : HIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTEDCPKSLLIPY` `:` `9im6(A) : HIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTEDCPKSLLIPY` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6xte(A) : LDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDF-------pQI` `:` `9im6(A) : LDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKHIVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFNDMEDDDPQI` `________________________________________________________________________________________________________________________` `______________636_______________________________________________________________________________________________________` `6xte(A) : SYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRV` `:` `9im6(A) : SYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFVNLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVRV` `______________636_______________________________________________________________________________________________________` `____________________________________________________________________________________________834_________________________` `6xte(A) : AAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTK` `:` `9im6(A) : AAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTK` `____________________________________________________________________________________________834_________________________` `________________________________________________________________________________________________________________________` `6xte(A) : VSDILHSIFSSYKEKVLPWFEQLLPLIVNLI-pHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYFLRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSK` `:` `9im6(A) : VSDILHSIFSSYKEKVLPWFEQLLPLIVNLICPHRPWPDRQWGLCIFDDVIEHCSPASFKYAEYFLRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSK` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6xte(A) : TKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLIESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIAQ` `:` `9im6(A) : TKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLIESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRLANVVRQVQTSGGLWTECIAQ` `________________________________________________________________________________________________________________________` `________________` `6xte(A) : LSPEQQAAIQELLNSA` `:` `9im6(A) : LSPEQQAAIQELLNSA` `________________`

Morph

Morph animation in progress.
Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Fixed Domain	Moving Domain	Rotation Angle	Translation (A)	Closure	Bending Residues
1	2	13.9	-0.1	83.0	214 - 215 219 - 225 232 - 233 240 - 241 247 - 248 253 - 254 256 - 257	Bending Region Analysis
1	3	19.6	-0.2	92.5	636 - 637 834 - 835 837 - 848	Bending Region Analysis
4	2	15.3	-0.5	31.6	83 - 84 108 - 109 118 - 119 121 - 122 124 - 125 163 - 165	Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 4

Movement classification: Hinge

PyMOL Script

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