DynDom - Protein Domain Motions

Importin Subunit Beta-3

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Importin Subunit Beta-3
Conformer 1 (PDB)	3w3t (A)
Conformer 2 (PDB)	3w3w (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	620	1.11	16 - 612 639 - 657 663 - 664 667 - 675 808 - 830 869 - 874
2	385	1.35	613 - 638 658 - 662 665 - 666 676 - 807 831 - 868 875 - 1086

Sequence

`________________________________________________________________________________________________________________________` `3w3t(A) : LPEEVNRTLLQIVQAFASdNQIRSVAEKALSEEW--eNNIEYLLTFLAEQAAFSQDTTVAALSAVLFRKLALKAPITHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECVQDDL` `:` `3w3w(A) : ALPEEVNRTLLQIVQAFASdNQIRSVAEKALSEEWITENNIEYLLTFLAEQAAFSQDTTVAALSAVLFRKLALKAPITHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECVQDDL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3t(A) : PAWPELLQALIESLKSGNPNFRESSFRILTTVPYLITAVDINSILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLGILLPSLLNSLPRFLDDGKDDALASVFESLIELVELAP` `:` `3w3w(A) : PAWPELLQALIESLKSGNPNFRESSFRILTTVPYLITAVDINSILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLGILLPSLLNSLPRFLDDGKDDALASVFESLIELVELAP` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3t(A) : KLFKDMFDQIIQFTDMVIKNKDLEPPARTTALELLTVFSENAPQMCKSNQNYGQTLVMVTLIMMTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYLQQ` `:` `3w3w(A) : KLFKDMFDQIIQFTDMVIKNKDLEPPARTTALELLTVFSENAPQMCKSNQNYGQTLVMVTLIMMTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYLQQ` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3t(A) : MITSTEWRERFAAMMALSSAAEGCADVLIGEIPKILDMVIPLINDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILEPYLDSL` `:` `3w3w(A) : MITSTEWRERFAAMMALSSAAEGCADVLIGEIPKILDMVIPLINDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILEPYLDSL` `________________________________________________________________________________________________________________________` `____________________________________________________________________________________________________________612_________` `3w3t(A) : LTNLLVLLQSNKLYVQEQALTTIAFIAEAAKNKFIKYYDTLMPLLLNVLKVnSVLKGKCMECATLIGFAVGKEKFHEHSQELISILVALQNSDdDALRSYLEQSWSRICRILGDDFVPLL` `:` `3w3w(A) : LTNLLVLLQSNKLYVQEQALTTIAFIAEAAKNKFIKYYDTLMPLLLNVLKVnSVLKGKCMECATLIGFAVGKEKFHEHSQELISILVALQNSd--ALRSYLEQSWSRICRILGDDFVPLL` `____________________________________________________________________________________________________________612_________` `______________638____645___________________________675__________________________________________________________________` `3w3t(A) : PIVIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDDKVSAMELLQSYATLLRGQFAVYVKEVMEEIALPSLDFYLHDGVRAAGATLIPILLSCLLAATeELVL` `:` `3w3w(A) : PIVIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDDKVSAMELLQSYATLLRGQFAVYVKEVMEEIALPSLDFYLHDGVRAAGATLIPILLSCLLAA-eELVL` `______________638____645___________________________675__________________________________________________________________` `___________________________________________________________807______820_______________________________________868___874_` `3w3t(A) : LWHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGVSANLTDTYERMQDRdEYNE-fTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWPMINTFLLDNEPIL` `:` `3w3w(A) : LWHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGVSANLTDTYERMQDRdEYNEdFTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWPMINTFLL--ePIL` `___________________________________________________________807______820_______________________________________868___874_` `________________________________________________________________________________________________________________________` `3w3t(A) : VIFALVVIGDLIQYeQTASMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYADVCIPTLDTLVQIVDgSKLEENRSSTENASAAIAKILYAY-----dTYTANWFKTLPTITD` `:` `3w3w(A) : VIFALVVIGDLIQYeQTASMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYADVCIPTLDTLVQIVDgSKLEENRSSTENASAAIAKILYAYNSNIPdTYTANWFKTLPTITD` `________________________________________________________________________________________________________________________` `__________________________________________________________________________` `3w3t(A) : KEAASFNYQFLSQLIENsNISAVVDSVIQALNERSLtVISSVKKLLGFLPSSDAMAIFNRYPADIMEKVHKWFA` `:` `3w3w(A) : KEAASFNYQFLSQvCAQSNISAVVDSVIQALNERSLtVISSVKKLLGFLPSSDAMAIFNRYPADIMEKVHKWF` `__________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	5.8
Translation (A)	-0.3
Closure (%)	91.0
Bending Residues ( green )	612 - 613 638 - 641 645 - 667 675 - 676 807 - 808 820 - 831 868 - 869 874 - 875
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

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