DynDom - Protein Domain Motions

Importin Subunit Beta-3

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Importin Subunit Beta-3
Conformer 1 (PDB)	3w3w (A)
Conformer 2 (PDB)	3w3z (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	495	1.68	522 - 526 529 - 1086
2	485	1.42	6 - 521 527 - 528

Sequence

`________________________________________________________________________________________________________________________` `3w3w(A) : ALPEEVNRTLLQIVQAFAS-dNQIRSVAEKALSEEWITENNIEYLLTFLAEQAAFSQDTTVAALSAVLFRKLALKAPITHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECVQDD` `:` `3w3z(A) : *LPEEVNRTLLQIVQAFASPDNQIRSVAEKALSEEW--eNNIEYLLTFLAEQAAFSQDTTVAALSAVLFRKLALK--iTHIRKEVLAQIRSSLLKGFLSERADSIRHKLSDAIAECVQDD` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3w(A) : LPAWPELLQALIESLKSGNPNFRESSFRILTTVPYLITAVDINSILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLGILLPSLLNSLPRFLDDGKDDALASVFESLIELVELA` `:` `3w3z(A) : LPAWPELLQALIESLKSGNPNFRESSFRILTTVPYLIT-------lPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLGILLPSLLNSLPRFLDDGKDDALASVFESLIELVELA` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3w(A) : PKLFKDMFDQIIQFTDMVIKNKDLEPPARTTALELLTVFSENAPQMCKSNQNYGQTLVMVTLIMMTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYLQ` `:` `3w3z(A) : PKLFKD-fDQIIQFTD-vIKNKDLEPPARTTALELLTVFSENAPQ-cKSNQNYGQTLV-vTLI--tEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYLQ` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3w(A) : QMITSTEWRERFAAMMALSSAAEGCADVLIGEIPKILDMVIPLINDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILEPYLDS` `:` `3w3z(A) : Q-iTSTEWRERFAA--aLSSAAEGCADVLIGEIPKILD-vIPLINDPHPRVQYGCCNVLGQISTDFSPFIQRTAHDRILPALISKLTSECTSRVQTHAAAALVNFSEFASKDILEPYLDS` `________________________________________________________________________________________________________________________` `__________________514___________________________________________________________________________________________________` `3w3w(A) : LLTNLLVLLQSNKLYVQEQALTTIAFIAEAAKNKFIKYYDTLMPLLLNVLKVnSVLKGKCMECATLIGFAVGKEKFHEHSQELISILVALQNSd-ALRSYLEQSWSRICRILGDDFVPLL` `:` `3w3z(A) : LLTNLLVLLQSNKLYVQEQALTTIAFIAEAAKNKFIKYYDTL-pLLLNVLK-nSVLKGKC-eCATLIGFAVGKEKFHEHSQELISILVALQNSDdALRSYLEQSWSRICRILGDDFVPLL` `__________________514___________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3w(A) : PIVIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDDKVSAMELLQSYATLLRGQFAVYVKEVMEEIALPSLDFYLHDGVRAAGATLIPILLSCLLAA-eELVL` `:` `3w3z(A) : PIVIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDDKVSA-eLLQSYATLLRGQFAVYVKEV-eEIALPSLDFYLHDGVRAAGATLIPILLSCLLAATeELVL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3w(A) : LWHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGVSANLTDTYERMQDRdEYNEdFTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWPMINTFLLePILVI` `:` `3w3z(A) : LWHKASSKLIGGL-sEP-pEITQVYHNSLVNGIKV-gDNCLSEDQLAAFTKGVSANLTDTYER-qDR------fTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWP-iNTFLL-pILVI` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3w3w(A) : FALVVIGDLIQYeQTASMKNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYADVCIPTLDTLVQIVDgSKLEENRSSTENASAAIAKILYAYNSNIPdTYTANWFKTLPTITDKE` `:` `3w3z(A) : FALVVIGDLIQYeQTAS-kNAFIPKVTECLISPDARIRQAASYIIGVCAQYAPSTYADVCIPTLDTLVQIVDgSKLEENRSSTENASAAIAKILYAYNSNIPdTYTANWFKTLPTITDKE` `________________________________________________________________________________________________________________________` `___________________________________________________________________________` `3w3w(A) : AASFNYQFLSQvCAQSNISAVVDSVIQALNERSLt----VISSVKKLLGFLPSSDAMAIFNRYPADIMEKVHKWF` `:` `3w3z(A) : AASFNYQFLSQLI--sNISAVVDSVIQALNERSLTEREtVISSVKKLLGFLPSSDA-aIFNRYPADI-eKVHKWF` `___________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	40.0
Translation (A)	-0.7
Closure (%)	96.0
Bending Residues ( green )	514 - 530
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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