Insulin Receptor Substrate 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Insulin Receptor Substrate 1
  Conformer 1
(PDB) 		1qqg (B)
  Conformer 2
(PDB) 		1qqg (A)
  Window Length 9
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 103 0.24   16 - 162
2 96 0.21   163 - 258

Sequence


           _________________________________________________________________________________________________________162____________ 
 1qqg(B) : SDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHaFKEVWQVILKPKGLG 
         :                                                                                                                          
 1qqg(A) : *DVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHaFKEVWQVILKPKGLG 
           _________________________________________________________________________________________________________162____________ 

           __________________________________________________________________________________________                               
 1qqg(B) : QTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSDEF                               
         :                                                                                                                          
 1qqg(A) : QTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAMSD**                               
           __________________________________________________________________________________________                               

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		2.4
Translation
(A) 		-0.2
Closure
(%) 		75.5
Bending Residues
( green ) 		  162 - 163
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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