DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor 5

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor 5
Conformer 1 (PDB)	8x0h (A)
Conformer 2 (PDB)	8x0h (B)
Window Length	11
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	478	1.14	30 - 518 523 - 536
2	290	1.15	519 - 522 537 - 822

Sequence

`________________________________________________________________________________________________________________________` `8x0h(A) : RRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLkPIVGVIGPGSSSVAIQVQNLLQLFNI` `:` `8x0h(B) : RRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDS--pIVGVIGPGSSSVAIQVQNLLQLFNI` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `8x0h(A) : PQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLL` `:` `8x0h(B) : PQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `8x0h(A) : MAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSM` `:` `8x0h(B) : MAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKMGFVINAIYSM` `________________________________________________________________________________________________________________________` `____________________________________________________________________________________________________________518_522_____` `8x0h(A) : AYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTAFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGE` `:` `8x0h(B) : AYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTAFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGE` `____________________________________________________________________________________________________________518_522_____` `______536_______________________________________________________________________________________________________________` `8x0h(A) : VSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQ` `:` `8x0h(B) : VSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQ` `______536_______________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `8x0h(A) : RIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVAPLGYNGLLILACTFYAFKTRNVPAN` `:` `8x0h(B) : RIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVAPLGYNGLLILACTFYAFKTRNVPAN` `________________________________________________________________________________________________________________________` `____________________________________________________________` `8x0h(A) : FNEAKYIAFAMYTTCIIWLAFVPIYFGSNYKAITMCFSVSLSATVLLGCMFVPKVYIILA` `:` `8x0h(B) : FNEAKYIAFAMYTTCIIWLAFVPIYFGSNYKAITMCFSVSLSATVLLGCMFVPKVYIILA` `____________________________________________________________`

Morph

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Status: Initialising

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	11.0
Translation (A)	0.0
Closure (%)	69.4
Bending Residues ( green )	518 - 519 522 - 523 536 - 537
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

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