DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor 5

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor 5
Conformer 1 (PDB)	8t8m (A)
Conformer 2 (PDB)	6n52 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	211	1.06	196 - 331 465 - 533 544 - 549
2	263	0.94	29 - 194 332 - 461
3	262	1.86	534 - 543 550 - 821

Sequence

`________________________________________________________________________________________________________________________` `8t8m(A) : RRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSL----------kPIVGVIGPGSSSVAIQ` `:` `6n52(A) : RVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEsFRSKKPIVGVIGPGSSSVAIQ` `________________________________________________________________________________________________________________________` `__________________________________194___________________________________________________________________________________` `8t8m(A) : VQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACF` `:` `6n52(A) : VQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACF` `__________________________________194___________________________________________________________________________________` `___________________________________________________331__________________________________________________________________` `8t8m(A) : CEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKM` `:` `6n52(A) : CEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKM` `___________________________________________________331__________________________________________________________________` `_____________________________________________________________461________________________________________________________` `8t8m(A) : GFVINAIYSMAYGLHNMQMS----------aMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEK` `:` `6n52(A) : GFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEK` `_____________________________________________________________461________________________________________________________` `_____________533_______543___549________________________________________________________________________________________` `8t8m(A) : GQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIA` `:` `6n52(A) : GQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIA` `_____________533_______543___549________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `8t8m(A) : KPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILrFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFN` `:` `6n52(A) : KPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIa--------CAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFN` `________________________________________________________________________________________________________________________` `_______________________________________________________________` `8t8m(A) : EAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIIL*****` `:` `6n52(A) : EAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERN` `_______________________________________________________________`

Morph

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Status: Initialising

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	30.2
Translation (A)	0.7
Closure (%)	99.6
Bending Residues ( green )	194 - 196 331 - 332 461 - 466
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	16.1
Translation (A)	-1.1
Closure (%)	99.8
Bending Residues ( green )	533 - 534 543 - 544 549 - 550
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

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