DynDom - Protein Domain Motions

Methionine Synthase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Methionine Synthase
Conformer 1 (PDB)	9cbo (A)
Conformer 2 (PDB)	9cbq (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	86	0.93	655 - 740
2	282	1.04	369 - 654
3	124	0.6	748 - 871

Sequence

`________________________________________________________________________________________________________________________` `9cbo(A) : QEASLFLVGERLNATGSKRFREMLFARDLEGILALAREQVEEGAHALDLSVAWTGRDELEDLRWLLPHLATALTVPVMVDSTSPEAMELALKYLPGRVLLNSANLEDGLERFDRVASLAK` `:` `9cbq(A) : ***SLFLVGERLNATGSKRFREMLFARDLEGILALAREQVEEGAHALDLSVAWTGRDELEDLRWLLPHLATALTVPVMVDSTSPEAMELALKYLPGRVLLNSANLEDGLERFDRVASLAK` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `9cbo(A) : AHGAALVVLAIDEKGMAKTREEKVRVALRMYERLTEHHGLRPEDLLFDLLTFPITQGDEESRPLAKETLLAMEELRERLPGVGFVLGVSNVSFGLKPRARRVLNSVFLDEARKRGLTAAI` `:` `9cbq(A) : AHGAALVVLAIDEKGMAKTREEKVRVALRMYERLTEHHGLRPEDLLFDLLTFPITQGDEESRPLAKETLLAMEELRERLPGVGFVLGVSNVSFGLKPRARRVLNSVFLDEARKRGLTAAI` `________________________________________________________________________________________________________________________` `_______________________________________645______________________________________________________________________________` `9cbo(A) : VDAGKILPISQIPEEAYALALDLIYDRRKEGFDPLLAFMAYFEAHKEDPGKREDAFLALPLLERLKRRVVEGRKQGLEADLEEALKAGHKPLDLINGPLLAGMKEVGDLFGAGKMQLPFV` `:` `9cbq(A) : VDAGKILPISQIPEEAYALALDLIYDRRKEGFDPLLAFMAYFE----dPGKREDAFLALPLLERLKRRVVEGRKQGLEADLEEALKAGHKPLDLINGPLLAGMKEVGDLFGAGKMQLPFV` `_______________________________________645______________________________________________________________________________` `____________738_________________________________________________________________________________________________________` `9cbo(A) : LQAAEVMKRAVAYLEPHMEKKGEGKGTLVLATVKGAVHDIGKNLVDIILSNNGYRVVNLGIKVPIEEILKAVEAHKPHAVGMSGLLVKSTLVMKENLEYMRDRGYTLPVILGGAALTRSY` `:` `9cbq(A) : LQAAEVMKRAVAYLEPH-------kGTLVLATVKGDVHGIGKNLVDIILSNNGYRVVNLGIKVPIEEILKAVEAHKPHAVGMSGLLVKSTLVMKENLEYMRDRGYTLPVILGGAALTRSY` `____________738_________________________________________________________________________________________________________` `______________________________` `9cbo(A) : VEELRAIYPNVYYAEDAFEGLRLMEELTGH` `:` `9cbq(A) : VEELRAIYPNVYYAEDAFEGLRLMEELTGH` `______________________________`

Morph

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	23.9
Translation (A)	2.4
Closure (%)	98.3
Bending Residues ( green )	645 - 655
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	35.2
Translation (A)	4.3
Closure (%)	56.9
Bending Residues ( green )	738 - 750
Bending Region Analysis