DynDom - Protein Domain Motions

Myosin Heavy Chain, Muscle

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Myosin Heavy Chain, Muscle
Conformer 1 (PDB)	5w1a (A)
Conformer 2 (PDB)	8exw (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	297	1.7	11 - 221 247 - 261 446 - 459 486 - 502 510 - 513 662 - 706
2	369	2.59	222 - 246 262 - 445 460 - 485 514 - 661
3	80	1.22	503 - 509 710 - 782
4	23	0.29	783 - 805

Sequence

`________________________________________________________________________________________________________________________` `5w1a(A) : QEDEDPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAIN` `:` `8exw(A) : EDEDPTPYLFVSLEQRRIDQSKPYDSKKSCWIPDEKEGYLLGEIKATKGDIVSVGLQGGETRDLKKDLLQQVNPPKYEKAEDMSNLTYLNDASVLHNLRQRYYNKLIYTYSGLFCVAIN` `________________________________________________________________________________________________________________________` `________________________________________________________________________202_________________________________________246_` `5w1a(A) : PYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFI` `:` `8exw(A) : PYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASK---------gSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFI` `________________________________________________________________________202_________________________________________246_` `___________261__________________________________________________________________________________________________________` `5w1a(A) : RIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDICLLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRG` `:` `8exw(A) : RIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKEMCFLSDNIYDYYNVSQGKVTVPNMDDGEEFQLADQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQRG` `___________261__________________________________________________________________________________________________________` `___________________________________________________________________________445___________459_______________________485__` `5w1a(A) : REEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQF` `:` `8exw(A) : REEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQF` `___________________________________________________________________________445___________459_______________________485__` `____________502_____510_________________________________________________________________________________________________` `5w1a(A) : FNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVD` `:` `8exw(A) : FNHIMFVMEQEEYKKEGINWDFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVD` `____________502_____510_________________________________________________________________________________________________` `______________________________________661__________________________________________706__________________________________` `5w1a(A) : QFKKSQNKLLIEIFADHAGQ-gGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYQILNPKGIKGIEDPKKC` `:` `8exw(A) : QFKKSQNKLLIEIFADHAGQkGGGFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYMILAPAIMAAEKVAKNA` `______________________________________661__________________________________________706__________________________________` `_______________________________________782___________________________` `5w1a(A) : TKVLIESTELNDDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQR*` `:` `8exw(A) : AGKCLEAVGLDPDMYRIGHTKVFFRAGVLGQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVA` `_______________________________________782___________________________`

Morph

Morph animation in progress.
Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.

play backwards

pause

play forwards

Domain Pairs

Fixed Domain	Moving Domain	Rotation Angle	Translation (A)	Closure	Bending Residues
1	2	22.8	1.7	97.3	202 - 222 246 - 247 261 - 262 445 - 446 459 - 460 485 - 486 510 - 516 661 - 664	Bending Region Analysis
1	3	26.1	-3.0	37.8	502 - 503 509 - 513 706 - 710	Bending Region Analysis
4	3	42.1	-0.1	100.0	782 - 783	Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 4

Movement classification:

No Contacts

PyMOL Script

Download and extract PyMOL PML script file

Download