DynDom - Protein Domain Motions

Piezo-Type Mechanosensitive Ion Channel Component 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Piezo-Type Mechanosensitive Ion Channel Component 1
Conformer 1 (PDB)	7wlt (A)
Conformer 2 (PDB)	7wlu (C)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	715	3.49	786 - 1327 1500 - 1709 1716 - 1976 1978 - 1978 1981 - 2038 2078 - 2080 2097 - 2098 2102 - 2103
2	560	5.85	1328 - 1499 1710 - 1715 1977 - 1977 1979 - 1980 2039 - 2077 2081 - 2096 2099 - 2101 2104 - 2545

Sequence

`________________________________________________________________________________________________________________________` `7wlt(A) : **********************************************************************************************************************` `:` `7wlu(C) : ELVTGIYVKYWIYVCAGMFIVVSFAGRLVVYKIVYMFLFLLCLTLFQVYYTLWRKLLRVFWWLVVAYTMLVLIAVYTFQFQDFPTYWRNLTGFTDEQLGDLGLEQFSVSELFSSILIPGF` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7wlt(A) : *********************LDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFALPYPRFRPMASCLSTVWTCIIIVCKMLYQLKIVNPnCTEPF` `:` `7wlu(C) : FLLACILQLHYFHRPFMQLTDLElDLAASFSAVLTRIQVFVRRLLELHVFKLVALYTVWVALKEVSVMNLLLVVLWAFALPYPRFRPMASCLSTVWTCIIIVCKMLYQLKIVNP------` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7wlt(A) :` `PqPLEINQSLLYRGPVDPANWFGVRKGYPNLGYIQNHLQILLLLVFEAVVYRRQEHYRRQH--rQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAILTR` `:` `7wlu(C) :` `---------------------fGVRKGYPNLGYIQNHLQILLLLVFEAVVYRRQEHYRRQHgTRQRLDQDLLSCLKYFINFFFYKFGLEICFLMAVNVIGQRMNFMVILHGCWLVAILTR` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7wlt(A) : RRREAIARLWPNYCLFLTLFLLYQYLLCLGm------------------NSALIKWLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQr--GEPNPIPNFIHCRSYLDMLK` `:` `7wlu(C) : RRREAIARLWPNYCLFLTLFLLYQYLLCLGMPPALCIDYPWRWSKAIPMNSALIKWLYLPDFFRAPNSTNLISDFLLLLCASQQWQVFSAERTEEWQRMAgEPNPIPNFIHCRSYLDMLK` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7wlt(A) : VAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQKDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSNFCWVIQLFSLVCTVKGYYDPKEMMTRDRDCLLP` `:` `7wlu(C) : VAVFRYLFWLVLVVVFVAGATRISIFGLGYLLACFYLLLFGTTLLQKDTRAQLVLWDCLILYNVTVIISKNMLSLLSCVFVEQMQSNFCWVIQLFSLVCTV-------------------` `________________________________________________________________________________________________________________________` `_________________________________________________1327___________________________________________________________________` `7wlt(A) :` `VEEAGIIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGFALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQASdHATVIHSGDYFLFESDSEE---------` `:` `7wlu(C) :` `--eAGIIWDSICFFFLLLQRRIFLSHYFLHVSADLKATALQASRGFALYNAANLKSINFHRQIEEKSLAQLKRQMKRIRAKQEKYRQSQAlDHATVIHSGDYFLFESDaFQMAYQAWVTN` `_________________________________________________1327___________________________________________________________________` `__________________________1499__________________________________________________________________________________________` `7wlt(A) :` `-----------------------hMMQRVLSTMQFLWVLGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLRVGEVRRGVLDQLaSELLLDRRLHIPELEEAERFEAQQGRTLR` `:` `7wlu(C) :` `AQTVLRQRRERARQERAEQLgRSHMMQRVLSTMQFLWVLGQATVDGLTRWLRAFTKHHRTMSDVLCAERYLLTQELLRVGEVRRGVLDQLaSELLLDRRLHIPELEEAERFEAQQGRTLR` `__________________________1499__________________________________________________________________________________________` `_______________________________1709__1715_______________________________________________________________________________` `7wlt(A) : LLRAGYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQFGFFPWNSYVVLRRYENKPYFPPRILGLEKTDSYIKYDLVQLMALF` `:` `7wlu(C) : LLRAGYQCVAAHSELLCYFIIILNHMVTASAASLVLPVLVFLWAMLTIPRPSKRFWMTAIVFTEVMVVTKYLFQF--------------------pPRILGLEKTDSYIKYDLVQLMALF` `_______________________________1709__1715_______________________________________________________________________________` `_____________________________________________1976__________________________________________________________2038_________` `7wlt(A) : FHRSQLLCYGLW------fCVSLAQSFYQPLQRFFHDILHTKYRAATDVYALMFLADIVDIIIIIFGFWAF----------------qVPQAFLFMLLVQFGTMVIDRALYLRKTVLGKL` `:` `7wlu(C) : FHRSQLLCYGLWDrRLQSFCVSLAQSFYQPLQRFFHDILHTKYRAATDVYALMFLADIVDIIIIIFGFWAFGKHSAATDIASSLSDDQVPQAFLFMLLVQFGTMVIDRALYLRKTVLGKL` `_____________________________________________1976__________________________________________________________2038_________` `__________________________2077_______________2096_______________________________________________________________________` `7wlt(A) : AFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKC` `:` `7wlu(C) : AFQVVLVVAIHIWMFFILPAVTERMFSQNAVAQLWYFVKCIYFALSAYQIRCGYPTRILGNFLTKKYNHLNLFLFQGFRLVPFLVELRAVMDWVWTDTTLSLSNWMCVEDIYANIFIIKC` `__________________________2077_______________2096_______________________________________________________________________` `________________________________________________________________________________________________________________________` `7wlt(A) : SRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIRSVVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPEDIVTAQIE` `:` `7wlu(C) : SRETEKKYPQPKGQKKKKIVKYGMGGLIILFLIAIIWFPLLFMSLIR-vVGVVNQPIDVTVTLKLGGYEPLFTMSAQQPSIVPFTPQAYEELSQQFDPYPLAMQFISQYSPEDIVTAQIE` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7wlt(A) : GSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEKHTLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLGVRIQLRR` `:` `7wlu(C) : GSSGALWRISPPSRAQMKQELYNGTADITLRFTWNFQRDLAKGGTVEYTNEKHTLELAPNSTARRQLAQLLEGRPDQSVVIPHLFPKYIRAPNGPEANPVKQLQPDEEEDYLGVRIQLRR` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `7wlt(A) : EQVGgTKASDFLEWWVIELQDCKADCNLLPMVIFSDKVSPPSLGFLAGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRS` `:` `7wlu(C) : EQVGgTKASDFLEWWVIELQDCKADCNLLPMVIFSDKVSPP-----aGYGIVGLYVSIVLVVGKFVRGFFSEISHSIMFEELPCVDRILKLCQDIFLVRETRELELEEELYAKLIFLYRS` `________________________________________________________________________________________________________________________` `____________` `7wlt(A) : PETMIKWTRERE` `:` `7wlu(C) : PETMIKWTRERE` `____________`

Morph

Morph animation in progress.
Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	32.4
Translation (A)	0.5
Closure (%)	85.1
Bending Residues ( green )	1327 - 1328 1499 - 1500 1709 - 1710 1715 - 1716 1976 - 1981 2038 - 2039 2077 - 2078 2080 - 2081 2096 - 2112
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

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