DynDom - Protein Domain Motions

Serum Albumin

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Serum Albumin
Conformer 1 (PDB)	5iiu (A)
Conformer 2 (PDB)	5ij5 (A)
Window Length	11
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	422	0.65	8 - 115 137 - 159 177 - 407 429 - 488
2	38	0.53	116 - 136 160 - 176
3	107	0.5	408 - 428 493 - 578

Sequence

`______________________________________________________________________________________________________________115_______` `5iiu(A) : HKSEIAHRFNDLGEKHFKGLVLVAFSQYLQQCPFEDHVKLVNEVTEFAKKCAADESAENCDKSLHTLFGDKLCTVATLRATYGELADCCEKQEPERNECFLTHKDDHPNLPKLKPEPDAQ` `:` `5ij5(A) : HKSEIAHRFNDLGEKHFKGLVLVAFSQYLQQCPFEDHVKLVNEVTEFAKKCAADESAENCDKSLHTLFGDKLCTVATLRATYGELADCCEKQEPERNECFLTHKDDHPNLPKLKPEPDAQ` `______________________________________________________________________________________________________________115_______` `___________136____________________159______________176__________________________________________________________________` `5iiu(A) : CAAFQEDPDKFLGKYLYEVARRHPYFYGPELLFHAEEYKADFTECCPADDKLACLIPKLDALKERILLSSAKERLKCSSFQNFGERAVKAWSVARLSQKFPKADFAEVSKIVTDLTKVHK` `:` `5ij5(A) : CAAFQEDPDKFLGKYLYEVARRHPYFYGPELLFHAEEYKADFTECCPADDKLACLIPKLDALKERILLSSAKERLKCSSFQNFGERAVKAWSVARLSQKFPKADFAEVSKIVTDLTKVHK` `___________136____________________159______________176__________________________________________________________________` `________________________________________________________________________________________________________________________` `5iiu(A) : ECCHGDLLECADDRADLAKYICEHQDSISGKLKACCDKPLLQKSHCIAEVKEDDLPSDLPALAADFAEDKEICKHYKDAKDVFLGTFLYEYSRRHPDYSVSLLLRIAKTYEATLEKCCAE` `:` `5ij5(A) : ECCHGDLLECADDRADLAKYICEHQDSISGKLKACCDKPLLQKSHCIAEVKEDDLPSDLPALAADFAEDKEICKHYKDAKDVFLGTFLYEYSRRHPDYSVSLLLRIAKTYEATLEKCCAE` `________________________________________________________________________________________________________________________` `__________________________________________407__________________428______________________________________________________` `5iiu(A) : ADPPACYRTVFDQFTPLVEEPKSLVKKNCDLFEEVGEYDFQNALIVRYTKKAPQVSTPTLVEIGRTLGKVGSRCCKLPESERLPCSENHLALALNRLCVLHEKTPVSEKITKCCTDSLAE` `:` `5ij5(A) : ADPPACYRTVFDQFTPLVEEPKSLVKKNCDLFEEVGEYDFQNALIVRYTKKAPQVSTPTLVEIGRTLGKVGSRCCKLPESERLPCSENHLALALNRLCVLHEKTPVSEKITKCCTDSLAE` `__________________________________________407__________________428______________________________________________________` `___488_______________________________________________________________________________________________` `5iiu(A) : RRPCFSALELDEGYVPKEFKAETFTFHADICTLPEDEKQIKKQSALAELVKHKPKATKEQLKTVLGNFSAFVAKCCGAEDKEACFAEEGPKLVASSQLALA` `:` `5ij5(A) : RRPCFSALELDEGYVPKEFKAETFTFHADICTLPEDEKQIKKQSALAELVKHKPKATKEQLKTVLGNFSAFVAKCCGAEDKEACFAEEGPKLVASSQLALA` `___488_______________________________________________________________________________________________`

Morph

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	8.0
Translation (A)	-0.4
Closure (%)	34.6
Bending Residues ( green )	115 - 116 136 - 137 159 - 161 176 - 177
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	5.8
Translation (A)	-0.5
Closure (%)	39.4
Bending Residues ( green )	407 - 409 428 - 429 488 - 501
Bending Region Analysis