Anthranilate phosphoribosyltransferase
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1gxb(C) : MNINEILKKLINKSDLEINEAEELAKAIIRGEVPEILVSAILVALRMKGE 
         :                                                    
 1o17(A) : MNINEILKKLINKSDLEINEAEELAKAIIRGEVPEILVSAILVALRMKGE 
           __________________________________________________ 

           ___________63_____________________________________ 
 1gxb(C) : SKNEIVGFARAMRELAIKIDVPNAIDTAGgLGTVNVSTASAILLSLVNPV 
         :                                                    
 1o17(A) : SKNEIVGFARAMRELAIKIDVPNAIDTAGgLGTVNVSTASAILLSLVNPV 
           ___________63_____________________________________ 

           __________________________________________149_____ 
 1gxb(C) : AKHGNRAVSGKSGSADVLEALGYNIIVPPERAKELVNKTNFVFLFAQYYH 
         :                                                    
 1o17(A) : AKHGNRAVSGKSGSADVLEALGYNIIVPPERAKELVNKTNFVFLFAQYYH 
           __________________________________________149_____ 

           _________________174______________________________ 
 1gxb(C) : PAMKNVANVRKTLGIRTIFNILGPLTNPANAKYQLMGVFSKDHLDLLSKS 
         :                                                    
 1o17(A) : PAMKNVANVRKTLGIRTIFNILGPLTNPANAKYQLMGVFSKDHLDLLSKS 
           _________________174______________________________ 

           __________________________________________________ 
 1gxb(C) : AYELDFNKIILVYGEPGIDEVSPIGNTFMKIVSKRGIEEVKLNVTDFGIS 
         :                                                    
 1o17(A) : AYELDFNKIILVYGEPGIDEVSPIGNTFMKIVSKRGIEEVKLNVTDFGIS 
           __________________________________________________ 

           __________________________________________________ 
 1gxb(C) : PIPIEKLIVNSAEDSAIKIVRAFLGKDEHVAEFIKINTAVALFALDRVGD 
         :                                                    
 1o17(A) : PIPIEKLIVNSAEDSAIKIVRAFLGKDEHVAEFIKINTAVALFALDRVGD 
           __________________________________________________ 

           _________________________________________          
 1gxb(C) : FREGYEYADHLIEKSLDKLNEIISMNGDVTKLKTIVVKSSG          
         :                                                    
 1o17(A) : FREGYEYADHLIEKSLDKLNEIISMNGDVTKLKTIVVKS**          
           _________________________________________          

Details

  Property   Value
 Conformer 1 1gxb(C)
 Conformer 2 1o17(A)
 Radius gyration for conformer 1 19.78 A
 Radius gyration for conformer 2 20.02 A
 EC Number 2.4.2.18.   2.4.2.18  
Click here to see the DynDom results or the famliy
 Trigger ligands POP1348
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ALA78  ASN89  ASP223  GLU224  GLY79  LYS106  SER118  SER91  THR92  VAL90 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT