PROTEIN (F1-ATPASE BETA CHAIN)
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2jdi(E) : TTGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTV 
         :                                                    
 1h8e(D) : TTGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTV 
           __________________________________________________ 

           __________________________________________________ 
 2jdi(E) : RTIAMDGTEGLVRGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGPI 
         :                                                    
 1h8e(D) : RTIAMDGTEGLVRGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGPI 
           __________________________________________________ 

           ____________________131___________________________ 
 2jdi(E) : KTKQFAAIHAEAPEFVEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGA 
         :                                                    
 1h8e(D) : KTKQFAAIHAEAPEFVEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGA 
           ____________________131___________________________ 

           __________171_____________________________________ 
 2jdi(E) : GVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINL 
         :                                                    
 1h8e(D) : GVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINL 
           __________171_____________________________________ 

           __________________________________________________ 
 2jdi(E) : KDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNI 
         :                                                    
 1h8e(D) : KDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNI 
           __________________________________________________ 

           __________________________________________________ 
 2jdi(E) : FRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQ 
         :                                                    
 1h8e(D) : FRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQ 
           __________________________________________________ 

           ___________________330____________________________ 
 2jdi(E) : AIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIM 
         :                                                    
 1h8e(D) : AIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIM 
           ___________________330____________________________ 

           __________________________________________________ 
 2jdi(E) : DPNIVGSEHYDVARGVQKILQDYKSLQDI--------lSEEDKLTVSRAR 
         :                                                    
 1h8e(D) : DPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRAR 
           __________________________________________________ 

           __________________________________________________ 
 2jdi(E) : KIQRFLSQPFQVAEVFTGHLGKLVPLKETIKGFQQILAGEYDHLPEQAFY 
         :                                                    
 1h8e(D) : KIQRFLSQPFQVAEVFTGHLGKLVPLKETIKGFQQILAGEYDHLPEQAFY 
           __________________________________________________ 

           _________________                                  
 2jdi(E) : MVGPIEEAVAKADKLA*                                  
         :                                                    
 1h8e(D) : MVGPIEEAVAKADKLAE                                  
           _________________                                  

Details

  Property   Value
 Conformer 1 2jdi(E)
 Conformer 2 1h8e(D)
 Radius gyration for conformer 1 24.7 A
 Radius gyration for conformer 2 24.67 A
 EC Number 3.6.3.14   3.6.1.34  
Click here to see the DynDom results or the famliy
 Trigger ligands ADP600
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ALA421  GLY157  GLY159  GLY161  LYS162  PHE418  PHE424  THR163  THR425  TYR345  VAL160  VAL164 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT