PROTEIN (F1-ATPASE BETA CHAIN)
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space)	domain 2 is binding domain(fixed in space)

Sequence

__________________________________________________   2jdi(E) : TTGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTV           :                                                      1h8e(E) : TTGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTV             __________________________________________________             __________________________________________________   2jdi(E) : RTIAMDGTEGLVRGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGPI           :                                                      1h8e(E) : RTIAMDGTEGLVRGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGPI             __________________________________________________             _____________124_______________________150________   2jdi(E) : KTKQFAAIHAEAPEFVEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGA           :                                                      1h8e(E) : KTKQFAAIHAEAPEFVEM--eQEILVTGIKVVDLLAPYAKGGKIGLFGGA             _____________124_______________________150________             ___________172____________________________________   2jdi(E) : GVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINL           :                                                      1h8e(E) : GVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINL             ___________172____________________________________             __________________________________________________   2jdi(E) : KDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNI           :                                                      1h8e(E) : KDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNI             __________________________________________________             __________________________________________________   2jdi(E) : FRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQ           :                                                      1h8e(E) : FRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQ             __________________________________________________             ____________________331__________________352_356__   2jdi(E) : AIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIM           :                                                      1h8e(E) : AIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIM             ____________________331__________________352_356__             __________________________________________________   2jdi(E) : DPNIVGSEHYDVARGVQKILQDYKSLQDI--------lSEEDKLTVSRAR           :                                                      1h8e(E) : DPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRAR             __________________________________________________             __________________________________________________   2jdi(E) : KIQRFLSQPFQVAEVFTGHLGKLVPLKETIKGFQQILAGEYDHLPEQAFY           :                                                      1h8e(E) : KIQRFLSQPFQVAEVFTGHLGKLVPLKETIKGFQQILAGEYDHLPEQAFY             __________________________________________________             ________________                                     2jdi(E) : MVGPIEEAVAKADKLA                                             :                                                      1h8e(E) : MVGPIE**********                                               ________________

Details

Property   Value  Conformer 1 2jdi(E)  Conformer 2 1h8e(E)  Radius gyration for conformer 1 24.39 A  Radius gyration for conformer 2 24.41 A  EC Number 3.6.3.14   3.6.1.34   Click here to see the DynDom results or the famliy  Trigger ligands ADP600  Trigger ligands in which conformation Conformation  2  Conformaton with trigger ligands is compact No  Spanning ligands Yes  Residues in enzyme contacting ligands ALA158  ALA421  GLY157  GLY159  GLY161  LYS162  PHE418  PHE424  THR163  TYR345  VAL160  VAL164   Residues in extended bending regions contacting ligands ALA158  GLY157  GLY159  GLY161  LYS162  THR163  VAL160   Residues in extended bending regions making H-bonds or salt-bridges with ligands GLY159  GLY161  LYS162  THR163  VAL160    Residues in extended bending regions with an H-bond between its main chain and ligands GLY159  GLY161  LYS162  THR163  VAL160  Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT