2-C-methyl-D-erythritol 2,4-cyclodiphosphate
Ligand-induced domain movement details

Jmol view of liganded conformation 1

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)





 1h48(E) : EAVALLIK                                           
 1h47(E) : EAVALLIK                                           


  Property   Value
 Conformer 1 1h48(E)
 Conformer 2 1h47(E)
 Radius gyration for conformer 1 15.16 A
 Radius gyration for conformer 2 15.16 A
 EC Number  
Click here to see the DynDom results or the famliy
 Trigger ligands C5P901
 Trigger ligands in which conformation Conformation  1
 Conformaton with trigger ligands is compact No
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA33  ASP56  ASP63  ASP8  GLY58  HIS10  HIS34  HIS42  ILE57  LEU76  LYS59  PHE61  PRO62  SER35 
 Residues in extended bending regions contacting ligands ASP56  GLY58  ILE57  LEU76  LYS59 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ASP56  ILE57 
  Residues in extended bending regions with an H-bond between its main chain and ligands ILE57 
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT